Table 5.

Clinical correlates of AFA in previous publications.

Study	Sample Size, n	Race	Clinical Association
Reimer, et al⁹	646 SSc, 22 AFA	NA	Lung, heart, and GI involvement
Okano, et al¹¹	416 SSc, 24 AFA	White, African American	Myositis, GI involvement, and PAH
Jacobsen, et al²⁵	230 SSc, 8 AFA	Mostly white	No clinical correlations were found for AFA within this group of patients
Tormey, et al⁴	1026 SSc, 42 AFA	White, Afro-Caribbean	DcSSc, isolated pulmonary HTN, and myositis
Aggarwal, et al⁶	2579 SSc, 108 AFA	White, African American	Skeletal muscle involvement and PAH
Sharif, et al¹⁷	278 SSc, 52 AFA	All African American	Digital ulcers and lower GI involvement
Steen, et al¹⁵	3148 SSc, 114 AFA	White, African American	PAH, GI involvement, and dcSSc
Nihtyanova, et al²⁶	398 SSc, 23 AFA	Mostly white	Pulmonary HTN
Current study	1544 SSc, 52 AFA	White, African descent, Native North American, and Australian	DcSSc, GI involvement, and mortality

AFA: antifibrillarin antibodies; SSc: systemic sclerosis; NA: not applicable; GI: gastrointestinal; HTN: hypertension; dcSSc: diffuse cutaneous SSc; PAH: pulmonary arterial HTN.