Inclusion criteria according to PICOS for the risk of incident gout and recurrent gout.
| Variables | Risk of Incident Gout | Risk of Recurrent Gout |
|---|---|---|
| Population | Gout-free individuals with available SUA data | Individuals with preexisting gout |
| Interventions/comparisons | SUA levels at baseline | SUA levels at baseline stratified by urate-lowering therapy use |
| Outcomes | Incident gout | Recurrent gout |
| Study design | Observational studies including prospective cohort studies/registries and retrospective cohort studies/database studies | Observational studies including prospective cohort studies/registries and retrospective cohort studies/database studies and randomized trials |
PICOS: Population, Intervention, Comparisons, Outcomes, and Study Design; SUA: serum uric acid.