Table 1.

Schedule for study dosing and PK sampling.

Cohort	Weeks 1–2	Week 3	Week 4	Weeks 5–6
Non-PK cohort, n = 16	ARH 600 mg	ARH 600 mg + FBX 80 mg	ARH 600 mg + FBX 40 mg	FBX 40 mg
PK cohort, n = 16	ARH 800 mg^†	ARH 800 mg + FBX 40 mg	ARH 800 mg + FBX 80 mg^‡	FBX 80 mg^§

↵† 24-h PK samples collected on Day 14.
↵‡ 24-h PK samples collected on Day 28.
↵§ 24-h PK samples collected on Day 42. PK: pharmacokinetic; ARH: arhalofenate; FBX: febuxostat.