ROC analysis: cutoffs for inflammatory h-MRI lesions for the definition of remission. Comparison between DAS28, SDAI, and the Boolean ACR/EULAR criteria.
| Inflammatory h-MRI | ROC Analysis | DAS28 ≤ 2.6, n = 119 | SDAI ≤ 3.3, n = 86 | Boolean ACR/EULAR Remission Criteria, n = 82 |
|---|---|---|---|---|
| RAMRIS bone edema, 0–69 | Cutoff point | 2 | 1 | 1 |
| S/Sp, % | 62.1/53.8 | 68.9/51.2 | 68.9/51.2 | |
| PPV/NPV, % | 75.2/38.6 | 83.2/31.9 | 83.2/31.9 | |
| AUC (95% CI) | 0.60 (0.54–0.66) | 0.62 (0.56–0.68) | 0.60 (0.53–0.67) | |
| RAMRIS synovitis, 0–21 | Cutoff point | 6 | 6 | 6 |
| S/Sp, % | 58.4/63.9 | 57.0/67.4 | 56.5/67.1 | |
| PPV/NPV, % | 78.5/40.4 | 86.0/30.9 | 86.5/29.3 | |
| AUC (95% CI) | 0.64 (0.58–0.70) | 0.64 (0.58–0.71) | 0.63 (0.57–0.70) | |
| Tenosynovitis, 0–26 | Cutoff point | 5 | 3 | 3 |
| S/Sp, % | 59.1/73.1 | 73.2/60.5 | 72.2/58.5 | |
| PPV/NPV, % | 81.0/38.6 | 86.7/39.1 | 86.7/36.1 | |
| AUC (95% CI) | 0.71 (0.65–0.76) | 0.69 (0.63–0.75) | 0.69 (0.63–0.75) | |
| Total inflammation, 0–116 | Cutoff point | 8 | 8 | 8 |
| S/Sp, % | 81.0/47.1 | 79.1/51.2 | 78.8/51.2 | |
| PPV/NPV, % | 77.6/52.3 | 85.1/41.1 | 85.8/39.3 | |
| AUC (95% CI) | 0.69 (0.63–0.74) | 0.68 (0.62–0.75) | 0.67 (0.60–0.73) |
ROC: receiver-operating characteristic; h-MRI: hand magnetic resonance imaging; DAS28: Disease Activity Scores on 28 joints; SDAI: Simplified Disease Activity Index; ACR: American College of Rheumatology; EULAR: European League Against Rheumatism; RAMRIS: Rheumatoid Arthritis Magnetic Resonance Imaging Scoring; S: sensitivity; Sp: specificity; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve.