Clinical features of 35 patients with SLE and severe TP. Values are % (n) or mean ± SEM unless otherwise specified.
| Clinical Features | Total, n = 35 | CR, n = 17 | PR, n = 8 | NR, n = 10 | p |
|---|---|---|---|---|---|
| Demographic data | |||||
| Sex, female/male, n | 30/5 | 14/3 | 8/0 | 8/2 | |
| Age, yrs | 34.3 ± 2.3 | 32.8 ± 3.2 | 32.6 ± 3.1 | 38.4 ± 5.4 | 0.550 |
| SLE disease courses, mos | 64.1 ± 12.7 | 49.1 ± 16.4 | 95.6 ± 35.4 | 64.2 ± 20.4 | 0.365 |
| TP disease courses, mos | 56.9 ± 13 | 47.1 ± 16.4 | 84.3 ± 37.8 | 51.8 ± 20.8 | 0.526 |
| Clinical data | |||||
| Arthralgia/arthritis | 40.0 (14) | 29.4 (5) | 62.5 (5) | 40.0 (4) | 0.300 |
| Nephritis | 45.7 (16) | 47.1 (8) | 25.0 (2) | 60.0 (6) | 0.341 |
| Neurological disease | 22.9 (8) | 29.4 (5) | 12.5 (1) | 20.0 (2) | 0.631 |
| Anemia | 48.6 (17) | 41.2 (7) | 37.5 (3) | 70.0 (7) | 0.282 |
| Leukopenia | 42.9 (15) | 35.3 (6) | 37.5 (3) | 60.0 (6) | 0.440 |
| Serositis | 17.1 (6) | 29.4 (5) | 0.0 (0) | 10.0 (1) | 0.157 |
| Mucocutaneous bleeding | 80.0 (28) | 64.7 (11) | 100.0 (8) | 90.0 (9) | 0.084 |
| Visceral hemorrhage | 11.4 (4) | 17.6 (3) | 12.5 (1) | 0.0 (0) | 0.388 |
| Other infections | 37.1 (13) | 35.3 (6) | 12.5 (1) | 60.0 (6) | 0.121 |
| Laboratory index | |||||
| Platelet before treatment | 19.5 ± 3.2 | 29.1 ± 5.25 | 6.1 ± 1.95 | 13.7 ± 3.4 | 0.010 |
| Anti-dsDNA positivity | 34.3 (12) | 35.3 (6) | 50.0 (4) | 20.0 (2) | 0.419 |
| Anti-dsDNA, IU/ml | 333 ± 65 | 370 ± 127 | 343 ± 52 | 205 ± 25 | 0.664 |
| Anti-Sm | 5.7 (2) | 0.0 (0) | 12.5 (1) | 10.0 (1) | 0.864 |
| Anti-SSA | 40.0 (14) | 41.2 (7) | 25.0 (2) | 50.0 (5) | 0.565 |
| Anti-SSB | 8.6 (3) | 11.8 (2) | 0.0 (0) | 10.0 (1) | 0.607 |
| Anti-RNP | 17.1 (6) | 17.6 (3) | 37.5 (3) | 0.0 (0) | 0.118 |
| aPL | 28.6 (10) | 29.4 (5) | 25.0 (2) | 30.0 (3) | 0.969 |
| Hypocomplementemia | 54.3 (19) | 58.8 (10) | 50.0 (4) | 50.0 (5) | 0.875 |
| PAIgG, ng/107 platelet, n = 15 | 2400 ± 754 (151∼8155) | 1948 ± 1070 (165∼8155) | 662 ± 262 (151∼1523) | 6351 ± 1051 (4272∼7660) | 0.011 |
| SLEDAI | 6.09 ± 1.08 | 6.35 ± 1.61 | 3.50 ± 0.80 | 7.70 ± 2.53 | 0.562 |
SEM: standard error of the mean; SLE: systemic lupus erythematosus; TP: thrombocytopenia; CR: complete response; PR: partial response; NR: no response; aPL: antiphospholipid antibodies; PAIgG: platelet-associated immunoglobulin G; SLEDAI: SLE Disease Activity Index.