Distinguishing the ability of 4 models to predict risk of SSc. The outpoint corresponding to maximum of the sum of sensitivity and specificity was considered the threshold.
| Model | Sensitivity | Specificity | AUC (95% CI) | Variate |
|---|---|---|---|---|
| Model A | 0.89 | 0.60 | 0.81 (0.78–0.84) | Sex, age, 5 CNV |
| Model B | 0.82 | 0.65 | 0.80 (0.77–0.83) | Sex, age, HLA-DQA1, APOBEC3A/3B |
| Model C | 0.99 | 0.45 | 0.75 (0.72–0.79) | Sex, HLA-DQA1, APOBEC3A/3B |
| Model D | 0.99 | 0.46 | 0.73 (0.69–0.76) | HLA-DQA1, APOBEC3A/3B |
SSc: systemic sclerosis; AUC: area under the curve; CNV: copy number variations.