Demographic characteristics and A439V NLRP3 mutation status in a family with FCAS/MWS-overlap syndrome. Values are n (%) unless otherwise specified.
| Characteristics | Values |
|---|---|
| No. family members | 37 |
| Male:female, n | 16:21 |
| Sex ratio, n | 1:1.3 |
| Ethnicity: white | 37 (100) |
| Family members with MWS-associated symptoms | 29 (78) |
| Family members with confirmed NLRP3 mutation | 15 (41) |
| Male:female, n | 9:6 |
| Sex ratio, n | 1:0.7 |
| Age at MWS diagnosis, mean (range) | 42 (12–75) |
| Symptomatic family members with the A439V mutation | 15/15 (100) |
| Family members without confirmed NLRP3 mutation | 22 (59) |
| Male:female, n | 7:15 |
| Sex ratio, n | 1:2 |
| Age at MWS diagnosis, mean (range) | 35 (6–70) |
| Symptomatic family members | 14/22 (64) |
FCAS: familial cold autoinflammatory syndrome; MWS: Muckle-Wells syndrome.