Table 5.

Prediction of remission at 6 months according to different remission definitions. Analyses are adjusted for rheumatoid factor, index year of DMARD start, and disease activity at start of DMARD, but results are not included. Values are OR (95% CI).

Variables	DAS28	SDAI	CDAI	ACR/EULAR Boolean	ACR/EULAR Boolean Practice	RAPID3
Age, yrs	1.00 (0.98–1.01)	0.99 (0.98–1.00)	0.99 (0.98–1.00)^*	0.99 (0.98–1.00)^*	0.99 (0.98–0.99)^**	0.98 (0.98–0.99)^***
Female sex	0.60 (0.49–0.73)^***	0.72 (0.57–0.92)^**	0.76 (0.61–0.94)^*	0.80 (0.62–1.03)	0.80 (0.64–1.01)	0.97 (0.80–1.17)
High education	1.37 (1.09–1.73)^**	1.14 (0.90–1.46)	1.14 (0.91–1.42)	1.27 (0.99–1.63)	1.16 (0.93–1.46)	1.36 (1.13–1.64)^**
Erosive disease	0.74 (0.60–0.91)^**	0.80 (0.62–1.04)	0.83 (0.66–1.06)	0.84 (0.64–1.09)	0.91 (0.71–1.16)	0.99 (0.81–1.21)
Current smoking	0.64 (0.52–0.82)^***	0.64 (0.49–0.85)^**	0.69 (0.53–0.88)^**	0.71 (0.54–0.93)^*	0.76 (0.59–0.97)^*	0.94 (0.78–1.15)
Disease duration, yrs,
0–0.5 yr, reference	1	1	1	1	1	1
> 0.5–1	0.89 (0.61–1.30)	0.75 (0.46–1.22)	0.83 (0.54–1.29)	0.62 (0.36–1.07)	0.70 (0.43–1.14)	1.03 (0.73–1.46)
> 1–5	0.64 (0.47–0.88)^**	0.76 (0.51–1.14)	0.80 (0.56–1.15)	0.75 (0.50–1.13)	0.70 (0.48–1.02)	0.84 (0.62–1.14)
> 5–10	0.79 (0.55–1.12)	0.69 (0.44–1.08)	0.79 (0.52–1.20)	0.73 (0.46–1.16)	0.75 (0.49–1.15)	0.91 (0.65–1.29)
> 10	0.71 (0.51–1.00)^*	0.71 (0.47–1.08)	0.75 (0.51–1.10)	0.81 (0.54–1.23)	0.76 (0.52–1.12)	0.78 (0.56–1.07)
Current treatment
non-MTX DMARD, reference	1	1	1	1	1	1
MTX monotherapy	0.89 (0.71–1.12)	1.08 (0.79–1.48)	0.99 (0.74–1.33)	0.97 (0.71–1.32)	1.03 (0.77–1.37)	0.91 (0.73–1.13)
bDMARD	1.52 (1.20–1.93)^**	1.86 (1.35–2.55)^***	1.94 (1.46–2.58)^***	1.57 (1.15–2.15)^**	1.61 (1.20–2.14)^**	1.26 (1.00–1.60)^*
mHAQ	0.83 (0.66–1.06)	0.60 (0.43–0.83)^**	0.56 (0.42–0.75)^***	0.69 (0.49–0.95)^*	0.62 (0.46–0.84)^**	0.49 (0.35–0.69)^***
Fatigue, per 10 mm	0.94 (0.91–0.98)^**	0.89 (0.85–0.94)^***	0.89 (0.86–0.93)^***	0.90 (0.86–0.95)^***	0.90 (0.86–0.94)^***	0.88 (0.85–0.92)^***
Previous DMARD use	0.69 (0.53–0.91)^**	0.72 (0.50–1.04)	0.64 (0.46–0.90)^**	0.76 (0.53–1.10)	0.80 (0.56–1.12)	0.64 (0.49–0.84)^**

↵* p < 0.05.
↵** p < 0.01.
↵*** p < 0.001. DMARD: disease-modifying antirheumatic drug; DAS28: Disease Activity Score at 28 joints; SDAI: Simplified Disease Activity Index; CDAI: Clinical Disease Activity Index; ACR: American College of Rheumatology; EULAR: European League Against Rheumatism; ACR/EULAR Boolean: ACR/EULAR Boolean remission definition; ACR/EULAR Boolean Practice: ACR/EULAR Boolean remission definition for clinical practice; RAPID3: Routine Assessment of Patient Index Data; MTX: methotrexate; bDMARD: biological DMARD; mHAQ: modified Health Assessment Questionnaire.