Table 3.

Fifteen children with untreated JDM and 5 healthy controls: clinical and laboratory associations. Diminished expression of miRNA-10a was significantly associated with the presence of the A allele at TNF-α-308 promoter region (p = 0.015). Values are mean ± SD unless otherwise specified (n = 15).

Variable	MiRNA-10a Relative Expression Levels	p	MiRNA-10b Relative Expression Levels	p

Sex	Girls 0.28 ± 0.13	0.41	Girls 0.44 ± 0.17	0.3
Sex	Boys 0.23 ± 0.13		Boys 0.35 ± 0.14
TNF-α-308A	G/G 0.30 ± 0.12	0.015	G/G 0.42 ± 0.14	0.55
TNF-α-308A	G/A 0.13 ± 0.03		G/A 0.36 ± 0.26
Race	White 0.24 ± 0.12	0.08	White 0.39 ± 0.15	0.5
Race	Non-white 0.37 ± 0.13		Non-white 0.48 ± 0.23

Variable	MiRNA-10a Pearson Correlation Coefficient	p	MiRNA-10b Pearson Correlation Coefficient	p

DAS SK	−0.23	0.4	0.24	0.39
DAS WK	−0.45	0.09	−0.13	0.65
DAS Total	−0.45	0.09	−0.05	0.85
ERL	−0.15	0.57	0.08	0.76
vWF:Ag	−0.5	0.06	−0.23	0.42
DUD	0.23	0.4	0.12	0.66
Age, yrs	−0.02	0.94	−0.09	0.73

JDM: juvenile dermatomyositis; TNF-α: tumor necrosis factor-α; miRNA: micro RNA; DAS SK: Disease Activity Score for skin; DAS WK: Disease Activity Score for muscle weakness; DAS Total: Disease Activity Score Total, the sum of DAS SK and DAS WK; ERL: end row loop; vWF:Ag: von Willebrand factor antigen; DUD: duration of untreated disease.