Anchor-based and distribution-based MCID values for scales in osteoarthritis (OA).
| Scale | MCID Improvement | MCID Deterioration | MCID Determined by Anchor Methods | MCID Determined by Distributional Methods | ||||
|---|---|---|---|---|---|---|---|---|
| ES | SRM | SEM | MDC90 | MDC95 | GRI | |||
| WOMAC pain* | ||||||||
| Knee and hip | −8.3 to −7.5 (n = 2) | 6.4 to 11 (n = 2) | — | — | — | — | — | — |
| Knee | −29.9 to −7.5 (n = 3) | 27.1 to 29.9 (n = 1) | 0.98 to 1.86 (n = 2) | 0.91 to 1.55 (n = 2) | 8.08 to 8.6 (n = 2) | — | 22.39 (n = 1) | 1.2 to 1.74 (n = 1) |
| Hip | −29.26 to 35.8 (n = 2) | −2.5 to 20 (n = 2) | 2.1 to 2.24 (n = 1) | 1.86 to 1.98 (n = 1) | 7.71 (n = 1) | — | 21.98 (n = 1) | 1.10 to 2.18 (n = 1) |
| WOMAC stiffness* | ||||||||
| Knee and hip | −10.1 to −7.2 (n = 2) | 2.9 to 5.1 (n = 2) | — | — | — | — | — | — |
| Knee | −20.84 to −6.3 (n = 2) | — | 0.51 to 1.69 (n = 2) | 0.40 to 1.32 (n = 2) | 4.73 (n = 1) | — | 13.11 (n = 1) | 1.16 to 1.31 (n = 1) |
| Hip | −25.91 (n = 1) | 1.79 (n = 1) | 1.61 to 1.81 (n = 1) | 1.39 to 1.53 (n = 1) | 10.1 (n = 1) | — | 27.98 (n = 1) | 0.81 to 1.12 (n = 1) |
| WOMAC function* | ||||||||
| Knee and hip | −8.0 to 6.7 (n = 2) | 10.3 to 13.3 (n = 2) | — | — | — | — | — | — |
| Knee | −33.5 to −5.3 (n = 6) | 32.8 to 33.9 (n = 1) | 0.66 to 1.32 (n = 3) | 0.64 to 1.13 (n = 3) | 4.6 to 10.5 (n = 2) | — | 29.12 (n = 1) | 0.56 to 0.62 (n = 1) |
| Hip | −26.54 to −9.42(n = 4) | 4.0 to 10.29 (n = 2) | 0.45 to 2.58 (n = 2) | 0.49 to 1.97 (n = 2) | 4.3 (n = 1) | — | 11.93 (n = 1) | 1.45 to 1.79 (n = 1) |
| WOMAC total* | ||||||||
| Knee and hip | −8.2 to 6.7 (n = 2) | 9.6 to 12.9 (n = 2) | — | — | — | — | — | — |
| Knee | −11.5 to 11.5 (n = 2) | — | 0.96 to 1.19 (n = 1) | 0.91 to 1.13 (n = 1) | 4.8 to 7.2 (n = 1) | 11.2 to 16.7 (n = 1) | 13.4 to 20 (n = 1) | 0.85 to 1.00 (n = 1) |
| Hip | −14.7 (n = 1) | — | — | — | — | — | — | — |
| SF-36 PF | ||||||||
| Knee and hip | 3.3 (n = 1) | −5.3 (n = 1) | — | — | — | — | — | — |
| Knee | 0.75 to 17.5 (n = 3) | — | 0.1 to 1.10 (n = 3) | 0.33 to 0.83 (n = 2) | 7.03 to 7.74 (n = 2) | 14.52 (n = 1) | 19.5 (n = 1) | 0.38 to 0.66 (n = 1) |
| Hip | 20.40 (n = 1) | −8.75 (n = 1) | 1.54 to 1.60 (n = 1) | 1.10 (n = 1) | 6.85 (n = 1) | — | 18.99 (n = 1) | 1.50 to 1.54 (n = 1) |
| SF-36 RP | ||||||||
| Knee | 3.77 to 13.16 (n = 2) | — | 0.21 to 1.15 (n = 3) | 0.2 to 0.69 (n = 2) | 6.08 to 9.73 (n = 2) | 14.38 (n = 1) | 26.97 (n = 1) | 0.28 (n = 1) |
| Hip | 10.78 (n = 1) | −20.0 (n = 1) | 1.23 to 1.72 (n = 1) | 0.74 to 0.99 (n = 1) | 8.19 (n = 1) | — | 22.71 (n = 1) | 0.26 (n = 1) |
| SF-36 BP | ||||||||
| Knee and hip | 7.8 (n = 1) | −7.2 (n = 1) | — | — | — | — | — | — |
| Knee | 6.69 to 20.35 (n = 2) | 0.56 to 0.66 (n = 3) | 0.45 to 0.57 (n = 2) | 10.28 to 13.86 (n = 2) | 24.93 (n = 1) | 37.91 (n = 1) | 0.21 to 0.65 (n = 1) | |
| Hip | 14.67 (n = 1) | −15.71 (n = 1) | 1.15 to 1.26 (n = 1) | 0.91 to 0.96 (n = 1) | 13.74 (n = 1) | — | 38.09 (n = 1) | 0.04 to 0.63 (n = 1) |
| SF-36 GH | ||||||||
| Knee | −7.3 to 9.58 (n = 2) | — | −0.07 to 0.32 (n = 2) | −0.07 to 0.16 (n = 2) | 8.43 to 9.88 (n = 2) | 15.15 (n = 1) | 27.4 (n = 1) | −0.31 to 0.04 (n = 1) |
| Hip | 0.40 (n = 1) | −1.71 (n = 1) | 0.09 to 0.25 (n = 1) | 0.09 to 0.27 (n = 1) | 10 (n = 1) | — | 27.73 (n = 1) | 0.04 to 0.63 (n = 1) |
| SF-36 VT | ||||||||
| Knee | 2.60 to 3.86 (n = 3) | — | 0.14 to 0.46 (n = 3) | 0.01 to 0.46 (n = 2) | 7.72 to 10.76 (n = 2) | 16.21 (n = 1) | 29.84 (n = 1) | 0.12 to 0.21 (n = 1) |
| Hip | 10.14 (n = 1) | −3.33 (n = 1) | 0.79 to 0.80 (n = 1) | 0.73 to 0.78 (n = 1) | 11.31 (n = 1) | — | 31.35 (n = 1) | 0.03 to 0.35 (n = 1) |
| SF-36 SF | ||||||||
| Knee | 6.15 to 11.66 (n = 2) | — | 0.04 to 0.57 (n = 3) | 0.29 to 0.58 (n = 2) | 8.7 to 14.87 (n = 2) | 24.33 (n = 1) | 41.23 (n = 1) | −0.31 to 0.04 (n = 1) |
| Hip | 8.63 (n = 1) | −27.08 (n = 1) | 0.72 to 0.74 (n = 1) | 0.69 to 0.71 (n = 1) | 15.17 (n = 1) | — | 42.05 (n = 1) | 0.55 to 0.83 (n = 1) |
| SF-36 RE | ||||||||
| Knee | 2.42 to 7.65 (n = 2) | — | 0.15 to 0.48 (n = 3) | 0.16 to 0.49 (n = 2) | 5.86 to 10.29 (n = 2) | 16.3 (n = 1) | 28.52 (n = 1) | 0.04 to 0.17 (n = 1) |
| Hip | −6.45 (n = 1) | −25.0 (n = 1) | 0.29 to 0.31 (n = 1) | 0.26 to 0.30 (n = 1) | 10.94 (n = 1) | — | 30.33 (n = 1) | 0.37 to 0.44 (n = 1) |
| SF-36 MH | ||||||||
| Knee | −0.32 to 4.48 (n = 2) | — | 0.13 to 0.32 (n = 3) | 0.12 to 0.34 (n = 2) | 7.34 to 8.73 (n = 2) | 14.14 (n = 1) | 24.19 (n = 1) | −0.02 to 0.16 (n = 1) |
| Hip | 8.99 (n = 1) | −12.0 (n = 1) | 0.54 to 0.56 (n = 1) | 0.54 to 0.60 (n = 1) | 8.42 (n = 1) | — | 23.33 (n = 1) | −0.13 (n = 1) |
| SF-36 nPCS | ||||||||
| Knee | 4.6 to 4.8 (n = 1) | 0.44 to 0.98 (n = 2) | 0.41 to 1.00 (n = 2) | |||||
| SF-36 nMCS | ||||||||
| Knee | 0.3 to 2.7 (n = 1) | 0.27 to 0.38 (n = 2) | 0.29 to 0.40 (n = 2) | |||||
↵* Scores standardized to 0–100 scale. n: number of articles; MCID: minimal clinically important difference; ES: effect size; SRM: standardized response mean; SEM: standard error of measurement; MDC90: minimum detectable change 90%; MDC95: minimum detectable change 95%; GRI: Guyatt’s responsiveness index; WOMAC: The Western Ontario and McMaster Universities Osteoarthritis Index; SF-36: Medical Outcomes Study Short Form-36; SF-36 PF: SF-36 physical functioning; SF-36 RP: SF-36 role physical; SF-36 BP: SF-36 bodily pain; SF-36 GH: SF-36 general health; SF-36 VT: SF-36 vitality; SF-36 SF: SF-36 social functioning; SF-36 RE: role emotional; SF-36 MH: SF-36 mental health; SF-36 nPCS: normalized physical component summary; SF-36 nMCS: normalized mental component summary.