Overall antirheumatic drug use and level of disease activity* among patients with rheumatoid arthritis (RA) according to calendar years 1996–2011.
| Calendar Year | No. RA Patients in the DNPR | Average No. DDD Per RA Patient, Per Yr | No. Patients with RA Who Had CRP Measurement | Median CRP, mg/l (IQR) |
|---|---|---|---|---|
| 1996 | 3432 | 145.0 | 343 | 20.5 (10.0–43.5) |
| 1997 | 3797 | 163.7 | 753 | 20.0 (10.8–43.3) |
| 1998 | 4168 | 239.0 | 979 | 19.0 (11.1–39.4) |
| 1999 | 4457 | 244.8 | 1796 | 15.5 (10.0–32.2) |
| 2000 | 4785 | 249.8 | 2589 | 13.6 (8.0–30.4) |
| 2001 | 5055 | 264.3 | 2882 | 14.7 (8.9–32.0) |
| 2002 | 5322 | 401.5 | 3095 | 15.0 (8.9–32.4) |
| 2003 | 5549 | 429.7 | 3274 | 13.3 (8.1–29.6) |
| 2004 | 5813 | 530.7 | 3501 | 12.1 (7.4–26.2) |
| 2005 | 6077 | 660.4 | 3697 | 11.6 (6.8–25.3) |
| 2006 | 6355 | 792.6 | 4576 | 11.2 (6.3–23.5) |
| 2007 | 6659 | 670.0 | 4818 | 10.8 (6.0–22.5) |
| 2008 | 6930 | 751.5 | 4862 | 10.4 (6.2–22.0) |
| 2009 | 7124 | 724.2 | 5590 | 10.0 (4.7–19.2) |
| 2010 | 7294 | 695.4 | 5828 | 10.0 (4.3–18.3) |
| 2011 | 7508 | — | 6137 | 10.0 (4.2–17.8) |
↵* Level of disease activity measured with median C-reactive protein (CRP) levels based on at least 1 CRP measurement per patient per year. DNPR: Danish National Patient Register; DDD: defined daily doses; IQR: interquartile range.