Variables | Parent, JNJ-40346527 | M7 | M2 | M7:P | M2:P | P + M7 + M2 | ||
---|---|---|---|---|---|---|---|---|
Cmax, ng/ml | Tmax*, h | Cmin, ng/ml | Cmin, ng/ml | Cmin, ng/ml | Cmin Ratio | Cmin Ratio | Cmin**, ng/ml | |
n | 25 | 25 | 25 | 25 | 25 | 24† | 24† | 25 |
Mean | 347 | 2.0 | 167 | 229 | 71.1 | 1.41 | 0.407 | 468 |
SD | 109 | (0.0–4.0) | 89.1 | 116 | 53.7 | 0.374 | 0.285 | 231 |
↵* Median and range reported instead of mean and SD.
↵** Total Cmin is calculated as the sum of the Cmin concentrations of parent (JNJ-40346527) and its metabolites (M7 and M2).
↵† As the Cmin value for 1 patient was below the limit of quantitation for the denominator, the ratio could not be calculated. P: parent (JNJ-40346527); C: concentration; M: metabolite; Cmax: maximum plasma JNJ-40346527 and metabolite concentration during a dosing interval at steady state; Cmin: minimum plasma JNJ-40346527 concentration during a dosing interval at steady state (may or may not be the trough concentration); Tmax: time to reach the maximum plasma JNJ-40346527 concentration.