Pretreatment | n | % of All Infusions | Infusions with Reactions | % with Reaction | OR | 95% CI | p Value vs None Group |
---|---|---|---|---|---|---|---|
IS as concomitant medication | |||||||
None | 4163 | 16.75 | 59 | 1.42 | |||
Any IS | 12,414 | 49.95 | 180 | 1.45 | 0.83 | 0.44–1.55 | 0.5487 |
MTX | 9364 | 37.68 | 142 | 1.52 | 0.82 | 0.43–1.58 | 0.5473 |
AZA/6-MP | 2073 | 8.34 | 24 | 1.16 | 0.81 | 0.04–18.01 | 0.5549 |
Corticosteroids | 4461 | 17.95 | 65 | 1.46 | 0.71 | 0.36–1.40 | 0.3106 |
Premedication | |||||||
None | 12,996 | 52.29 | 148 | 1.14 | |||
Any pretreatment | 11,856 | 47.71 | 174 | 1.47 | 1.19 | 0.94–1.49 | 0.1491 |
Acetaminophen | 8424 | 33.90 | 93 | 1.10 | 0.97 | 0.74–1.27 | 0.8151 |
Antihistamines | 5672 | 22.82 | 127 | 2.24 | 1.58 | 1.22–2.07 | 0.0007 |
Diphenhydramine | 3567 | 14.35 | 94 | 2.64 | 1.71 | 1.26–2.31 | 0.0007 |
Second-generation antihistamines | 2159 | 8.69 | 35 | 1.62 | 1.55 | 1.04–2.31 | 0.0332 |
Loratadine* | 514 | 2.07 | 5 | 0.97 | 0.85 | 0.26–2.76 | 0.7416 |
Desloratadine | 1645 | 6.62 | 30 | 1.82 | 1.51 | 0.98–2.31 | 0.0600 |
Steroids | 5588 | 22.49 | 105 | 1.88 | 1.50 | 1.13–2.01 | 0.0057 |
Acetaminophen alone | 3508 | 14.12 | 20 | 0.57 | 0.61 | 0.38–0.98 | 0.0426 |
Antihistamines alone | 1059 | 4.26 | 31 | 2.93 | 1.79 | 1.13–2.82 | 0.0129 |
Steroids alone | 1243 | 5.00 | 14 | 1.13 | 1.00 | 0.53–1.92 | 0.9900 |
Steroids + antihistamines | 859 | 3.46 | 33 | 3.84 | 3.34 | 2.05–5.43 | < 0.0001 |
Steroids + acetaminophen | 1162 | 4.68 | 12 | 1.03 | 0.91 | 0.49–1.66 | 0.7447 |
Antihistamines + acetaminophen | 1387 | 5.58 | 13 | 0.94 | 1.13 | 0.61–2.09 | 0.6956 |
Steroids + antihistamines + acetaminophen | 2101 | 8.45 | 37 | 1.76 | 1.44 | 0.97–2.15 | 0.0701 |
↵* Because of the lack of statistical power, propensity scores adjustment could not be performed for loratadine. Significant data are in bold face. IS: immunosuppressant; MTX: methotrexate; AZA: azathioprine; 6-MP: 6-mercaptopurine.