Ratio between plasma and SF concentration of lectin pathway proteins. T was calculated using a paired Student t test. Values are given as median (IQR) unless otherwise specified.
| Variables | Plasma, μg/ml | SF, μg/ml | n | Plasma/SF Ratio | t | p |
|---|---|---|---|---|---|---|
| Oligoarticular JIA | ||||||
| MBL | 2.25 (0.60–4.11) | 0.87 (0.33–1.75) | 36 | 2.17 (1.68–2.86) | 6.9 | < 0.001 |
| M-ficolin | 1.74 (1.37–2.36) | 0.39 (0.20–0.84) | 38 | 3.83 (2.08–9.41) | 7.8 | < 0.001 |
| H-ficolin | 21.80 (18.27–24.25) | 9.48 (7.20–13.2) | 36 | 2.34 (1.67–3.09) | 13.6 | < 0.001 |
| MASP-1 | 14.65 (10.90–17.09) | 4.35 (3.16–6.03) | 36 | 3.18 (2.01–5.05) | 9.0 | < 0.001 |
| MASP-2 | 0.32 (0.25–0.39) | 0.11 (0.07–0.19) | 38 | 2.87 (1.86–4.00) | 9.3 | < 0.001 |
| MASP-3 | 4.17 (3.22–5.00) | 8.07 (4.72–11.3) | 36 | 0.61 (0.29–0.86) | −6.2 | < 0.001 |
| MAp19 | 0.33 (0.22–0.43) | 0.10 (0.06–0.16) | 36 | 3.03 (2.15–3.97) | 12.8 | < 0.001 |
| MAp44 | 1.94 (1.73–2.32) | 1.19 (0.89–0.14) | 38 | 1.84 (1.37–2.26) | 6.9 | < 0.001 |
| Systemic JIA | ||||||
| MBL | 1.47 (0.38–2.64) | 0.40 (0.04–1.18) | 11 | 2.02 (1.28–15.9) | 1.8 | 0.108 |
| M-ficolin | 4.04 (2.50–5.89) | 1.34 (0.71–2.07) | 11 | 3.85 (2.14–4.62) | 4.7 | 0.001 |
| H-ficolin | 24.45 (22.38–33.17) | 17.76 (14.42–22.94) | 11 | 1.43 (1.07–2.23) | 2.3 | 0.042 |
| MASP-1 | 6.86 (5.53–8.96) | 3.96 (2.26–4.83) | 9 | 2.12 (1.48–3.62) | 5.9 | < 0.001 |
| MASP-2 | 0.60 (0.46–0.91) | 0.34 (0.15–0.48) | 11 | 2.07 (1.77–3.02) | 5.5 | < 0.001 |
| MASP-3 | 2.97 (2.50–3.58) | 8.32 (5.19–10.61) | 11 | 0.30 (0.28–0.56) | −5.1 | < 0.001 |
| MAp19 | 0.46 (0.39–0.54) | 0.23 (0.16–0.32) | 10 | 2.43 (1.53–2.84) | 5.0 | 0.001 |
| MAp44 | 2.21 (1.87–2.49) | 1.01 (0.80–1.41) | 11 | 2.16 (1.51–3.08) | 7.3 | < 0.001 |
SF: synovial fluid; IQR: interquartile range; JIA: juvenile idiopathic arthritis; MBL: mannan-binding lectin; MASP: MBL-associated serine proteases; MAp: MBL-associated proteins.