Adjusted associations between disease severity measures in pregnant women with RA with pregnancy outcomes in the OTIS cohort (n = 440), 2005–2013.
| Disease Severity Measures | Preterm Delivery*, n = 66/439 | SGA**, n = 39/432 | Cesarean Delivery†, n = 182/437 | |||
|---|---|---|---|---|---|---|
| Crude RR‡ (95% CI) | aRR‡ (95% CI) | Crude RR‡ (95% CI) | aRR‡ (95% CI) | Crude RR‡ (95% CI) | aRR‡ (95% CI) | |
| HAQ-DI, 0–3 | 1.75 (1.37–2.34) | 1.58 (1.17–2.15) | 1.23 (1.08–1.89) | 1.31 (0.85–2.03) | 1.17 (0.99–1.38) | 1.15 (0.97–1.36) |
| HAQ-DI > 0.5 | 1.66 (1.06–2.58) | 1.48 (0.95–2.23) | 1.82 (1.01–3.29) | 1.81 (1.01–3.33) | 1.18 (0.94–1.48) | 1.04 (0.91–1.42) |
| PS, /20 units | 1.19 (1.03–1.39) | 1.18 (1.20–1.38) | 1.19 (0.98–1.44) | 1.21 (1.00–1.47) | 1.05 (0.98–1.14) | 1.05 (0.98–1.13) |
| PGS, /20 units | 1.27 (1.09–1.48) | 1.23 (1.05–1.45) | 1.22 (0.99–1.51) | 1.22 (0.99–1.51) | 1.03 (0.95–1.12) | 1.03 (0.95–1.12) |
↵* Adjusted for previous preterm delivery, maternal age at delivery, prednisone (≥ 10 mg anytime during pregnancy), maternal education, and gestational age at enrollment.
↵** Adjusted for Crohn disease, in vitro fertilization, and gestational age at enrollment.
↵† Adjusted for maternal age, periconceptional use of vitamins containing folic acid, and gestational age at enrollment.
↵‡ Using modified Poisson regression models. RA: rheumatoid arthritis; OTIS: Organization of Teratology Information Specialists Autoimmune Diseases in Pregnancy Project; SGA: small for gestational age; crude RR: crude relative risk; aRR: adjusted relative risk; HAQ-DI: Health Assessment Questionnaire–Disability Index measured in early pregnancy — for the continuous HAQ-DI, for every unit (0–1) increase, functional disability was configured using HAQ-DI > 0.5; PS: pain score; PGS: patient global score. Prednisone (≥ 10 mg anytime during pregnancy) was an independent predictor of preterm delivery (p = 0.009), but not for SGA.