APPENDIX 1.

Correlation coefficient of components disease activity at W14 and serum IFX level at W6 to W14 with disease activity, HAQ score, and ΔTSS at W54.

Correlation	3 mg/kg, n = 99		6 mg/kg, n = 104		10 mg/kg, n = 104
	Coefficient	p	Coefficient	p	Coefficient	p
With SDAI at W54
TJC28 at W14	0.585	< 0.0001	0.401	< 0.0001	0.429	< 0.0001
SJC28 at W14	0.465	< 0.0001	0.420	< 0.0001	0.278	0.0042
CRP at W14	0.475	< 0.0001	0.385	< 0.0001	0.378	< 0.0001
PtGA at W14	0.486	< 0.0001	0.526	< 0.0001	0.394	< 0.0001
PGA at W14	0.534	< 0.0001	0.566	< 0.0001	0.300	0.0020
Serum IFX level at W6^*	−0.194	0.0544	−0.420	< 0.0001	−0.355	0.0002
Serum IFX level at W10^*^†	−0.313	0.0016	−0.449	< 0.0001	−0.365	0.0002
Serum IFX level at W14^*	−0.246	0.0142	−0.448	< 0.0001	−0.385	< 0.0001
With DAS28-CRP at W54
TJC28 at W14	0.568	< 0.0001	0.454	< 0.0001	0.404	< 0.0001
SJC28 at W14	0.425	< 0.0001	0.475	< 0.0001	0.238	0.0151
CRP at W14	0.475	< 0.0001	0.456	< 0.0001	0.389	< 0.0001
PtGA at W14	0.490	< 0.0001	0.598	< 0.0001	0.395	< 0.0001
PGA at W14	0.500	< 0.0001	0.607	< 0.0001	0.358	0.0002
Serum IFX level at W6^*	−0.232	0.0212	−0.466	< 0.0001	−0.384	< 0.0001
Serum IFX level at W10^*^†	−0.341	0.0005	−0.493	< 0.0001	−0.406	< 0.0001
Serum IFX level at W14^*	−0.297	0.0028	−0.484	< 0.0001	−0.432	< 0.0001
With HAQ at W54
TJC28 at W14	0.362	0.0002	0.370	0.0001	0.420	< 0.0001
SJC28 at W14	0.277	0.0055	0.316	0.0011	0.145	0.1411
CRP at W14	0.255	0.0109	0.302	0.0018	0.251	0.0100
PtGA at W14	0.501	< 0.0001	0.573	< 0.0001	0.354	0.0002
PGA at W14	0.397	< 0.0001	0.503	< 0.0001	0.365	0.0001
Serum IFX level at W6^*	−0.062	0.5400	−0.106	0.2849	−0.213	0.0298
Serum IFX level at W10^*^†	−0.180	0.0744	−0.183	0.0626	−0.243	0.0135
Serum IFX level at W14^*	−0.117	0.2474	−0.177	0.0723	−0.280	0.0039
With ΔTSS at W54^‡
TJC28 at W14^*	−0.052	0.6320	0.053	0.6150	0.013	0.8975
SJC28 at W14^*	−0.037	0.7342	0.079	0.4551	0.028	0.7876
CRP at W14^*	0.239	0.0269	0.122	0.2479	0.192	0.0625
PtGA at W14^*	0.192	0.0761	0.170	0.1045	0.045	0.6667
PGA at W14^*	0.249	0.0206	0.242	0.0199	0.132	0.2027
Serum IFX level at W6^*	−0.141	0.1946	−0.143	0.1736	−0.103	0.3205
Serum IFX level at W10^*	−0.177	0.1028	−0.174	0.0973	−0.046	0.6593
Serum IFX level at W14^*	−0.158	0.1460	−0.127	0.2275	−0.057	0.5832

Correlations of components of disease activity at W14 and serum IFX levels at W6 to W14 with disease activity, HAQ score and ΔTSS at W54 were calculated using Pearson correlation coefficient or
↵* Spearman rank correlation coefficient.
↵† n = 103 in 10 mg/kg group.
↵‡ n = 86, 92, and 95 in 3, 6, and 10 mg/kg groups, respectively. W14: Week 14; IFX: infliximab; W6: Week 6; HAQ: Health Assessment Questionnaire; ΔTSS: change in total modified Sharp score; W54: Week 54; SDAI: Simplified Disease Activity Index; TJC28: tender joint count in 28 joints; SJC28: swollen joint count in 28 joints; CRP: C-reactive protein; PtGA: patient’s global assessment; PGA: physician’s global assessment; W10: Week 10; DAS28: 28-joint Disease Activity Score.