Correlation | 3 mg/kg, n = 99 | 6 mg/kg, n = 104 | 10 mg/kg, n = 104 | |||
---|---|---|---|---|---|---|
Coefficient | p | Coefficient | p | Coefficient | p | |
With SDAI at W54 | ||||||
SDAI at W6 | 0.563 | < 0.0001 | 0.453 | < 0.0001 | 0.260 | 0.0078 |
SDAI at W10 | 0.703 | < 0.0001 | 0.513 | < 0.0001 | 0.274 | 0.0049 |
SDAI at W14 | 0.665 | < 0.0001 | 0.547 | < 0.0001 | 0.500 | < 0.0001 |
ΔSDAI at W14 | −0.292 | 0.0034 | −0.298 | 0.0022 | −0.477 | < 0.0001 |
Improvement, %, of SDAI at W14 | −0.541 | < 0.0001 | −0.501 | < 0.0001 | −0.612 | < 0.0001 |
With DAS28-CRP at W54 | ||||||
DAS28-CRP at W6 | 0.548 | < 0.0001 | 0.537 | < 0.0001 | 0.364 | 0.0001 |
DAS28-CRP at W10 | 0.662 | < 0.0001 | 0.608 | < 0.0001 | 0.440 | < 0.0001 |
DAS28-CRP at W14 | 0.666 | < 0.0001 | 0.666 | < 0.0001 | 0.553 | < 0.0001 |
ΔDAS28-CRP at W14 | −0.497 | < 0.0001 | −0.522 | < 0.0001 | −0.564 | < 0.0001 |
Improvement, %, of DAS28-CRP at W14 | −0.579 | < 0.0001 | −0.613 | < 0.0001 | −0.598 | < 0.0001 |
With HAQ at W54 | ||||||
SDAI at W6 | 0.392 | < 0.0001 | 0.420 | < 0.0001 | 0.241 | 0.0139 |
DAS28-CRP at W6 | 0.435 | < 0.0001 | 0.426 | < 0.0001 | 0.315 | 0.0011 |
SDAI at W10 | 0.513 | < 0.0001 | 0.439 | < 0.0001 | 0.280 | 0.0040 |
DAS28-CRP at W10 | 0.547 | < 0.0001 | 0.432 | < 0.0001 | 0.364 | 0.0001 |
SDAI at W14 | 0.455 | < 0.0001 | 0.486 | < 0.0001 | 0.430 | < 0.0001 |
ΔSDAI at W14 | −0.281 | 0.0048 | −0.151 | 0.1252 | −0.356 | 0.0002 |
Improvement, %, of SDAI at W14 | −0.441 | < 0.0001 | −0.371 | 0.0001 | −0.490 | < 0.0001 |
DAS28-CRP at W14 | 0.486 | < 0.0001 | 0.505 | < 0.0001 | 0.458 | < 0.0001 |
ΔDAS28-CRP at W14 | −0.434 | < 0.0001 | −0.283 | 0.0036 | −0.404 | < 0.0001 |
Improvement, %, of DAS28-CRP at W14 | −0.492 | < 0.0001 | −0.375 | < 0.0001 | −0.465 | < 0.0001 |
With ΔTSS at W54† | ||||||
SDAI at W6* | −0.046 | 0.6713 | 0.110 | 0.2956 | −0.012 | 0.9088 |
DAS28-CRP at W6* | −0.035 | 0.7488 | 0.173 | 0.1001 | 0.092 | 0.3756 |
SDAI at W10* | 0.022 | 0.8398 | 0.175 | 0.0956 | 0.021 | 0.8384 |
DAS28-CRP at W10* | 0.071 | 0.5133 | 0.170 | 0.1058 | 0.089 | 0.3917 |
SDAI at W14* | 0.096 | 0.3775 | 0.105 | 0.3195 | 0.028 | 0.7903 |
ΔSDAI at W14* | −0.257 | 0.0168 | −0.159 | 0.1300 | −0.038 | 0.7139 |
Improvement, %, of SDAI at W14* | −0.217 | 0.0444 | −0.143 | 0.1743 | −0.021 | 0.8401 |
DAS28-CRP at W14* | 0.115 | 0.2929 | 0.108 | 0.3056 | 0.089 | 0.3916 |
ΔDAS28-CRP at W14* | −0.255 | 0.0179 | −0.165 | 0.1151 | −0.084 | 0.4200 |
Improvement, %, of DAS28-CRP at W14* | −0.216 | 0.0462 | −0.162 | 0.1225 | −0.070 | 0.4981 |
Coefficients and p values were evaluated using Pearson correlation coefficient or
↵* Spearman rank correlation coefficient.
↵† n = 86, 92, and 95 in the 3 mg/kg, 6 mg/kg, and 10 mg/kg groups, respectively. W6: Week 6; W10: Week 10; W14: Week 14; HAQ: Health Assessment Questionnaire; ΔTSS: change in modified total Sharp score; W54: Week 54; SDAI: Simplified Disease Activity Index; ΔSDAI: improvement value of SDAI; DAS28-CRP: 28-joint Disease Activity Score-C-reactive protein; ΔDAS28-CRP: improvement value of DAS28-CRP.