COMP | Happonen, et al, 201036 | Regulates complement |
Collagen IX (NC4 domain) | Kalchishkova, et al, 201138 | Direct/indirect inhibition of complement |
Fibromodulin | Sjoberg A, et al, 200537 | Activates classical complement pathway through C1q |
Fibromodulin | Wang, et al, 201135 | Upregulates C5b-9 (MAC) from human OA sera |
Fibronectin (EC domain) | Okamura, et al, 200129 | Triggers TLR-4 |
Fibronectin (EC domain) | Gondokaryono, et al, 200730 | Triggers TLR-4 mast cells |
Hyaluronan (HA) | Yamasaki, et al, 200965 | Triggers inflammasome > IL-1β |
HA | Scheibner, et al, 200631 | Triggers TLR-2 |
HA | Taylor, et al, 200732 | Triggers TLR4/CD44/MD-2 |
Tenascin-C | Midwood, et al, 200923 | TLR-4 agonist leading to persistent synovial inflammation |
COMP: cartilage oligomeric matrix protein; MAC: membrane attack complex; OA: osteoarthritis; TLR: Toll-like receptor.