Clinical characteristics of patients. All values presented as n (%) or mean ± SD unless otherwise specified.
| Characteristics | AOSD, n = 37 | HC, n = 38 |
|---|---|---|
| Age, yrs | 40.3 ± 13.7 | 37.9 ± 7.5 |
| Sex, female/male | 32/5 | 36/2 |
| Fever | 35 (94.6) | — |
| Sore throat | 21 (56.8) | — |
| Skin rash | 29 (78.4) | — |
| Lymphadenopathy | 16 (43.2) | — |
| Splenomegaly | 14 (37.8) | — |
| Hepatomegaly | 6 (16.2) | — |
| Pericarditis | 7 (18.9) | — |
| Pleuritis | 6 (16.2) | — |
| Arthralgia | 36 (97.3) | — |
| Arthritis | 23 (62.2) | — |
| Hemoglobin, g/dl | 11.3 ± 1.8 | — |
| Leukocyte, /µl | 14,286 ± 4489 | — |
| Platelet, × 103/µl | 312.3 ± 112.1 | — |
| Ferritin, ng/ml | 4862 ± 9277.1 | 47.4 ± 54.7 |
| ESR, mm/hr | 69.2 ± 24.8 | — |
| CRP, mg/dl | 8.76 ± 5.34 | 0.09 ± 0.21 |
| AST, mg/dl | 82.8 ± 103.6 | — |
| ALT, mg/dl | 88.4 ± 110.4 | — |
| ANA positivity | 6 (16.2) | — |
| RF positivity | 6 (16.2) | — |
| Systemic score | 5.38 ± 1.36 | — |
Systemic score by Pouchot, et al3 assigns a score from 0 to 12 and adds 1 point for each of the following manifestations: fever, typical rash, pleuritis, pneumonia, pericarditis, hepatomegaly or abnormal liver function tests, splenomegaly, lymphadenopathy, leukocytosis ≥ 15,000/mm2, sore throat, myalgia, and abdominal pain. AOSD: adult-onset Still’s disease; HC: healthy control; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; AST: aspartate transaminase; ALT: alanine transaminase; ANA: antinuclear antibody; RF: rheumatoid factor.