DACV, n = 239 | Other CV, n = 534 | p | |
---|---|---|---|
Demographic data | |||
Age, yrs, mean ± SD | 36 ± 28 | 33 ± 27 | 0.2 |
Sex, n (%) | |||
Men | 133 (55.6) | 289 (54.1) | 0.7 |
Women | 106 (44.4) | 245 (45.9) | |
Other precipitating events, n (%) | |||
Infection | 164 (68.6) | 121 (22.7) | < 0.01 |
Underlying connective diseases | 2 (0.8) | 36 (6.7) | < 0.01 |
Clinical manifestations, n (%) | |||
Skin lesions | |||
Palpable purpura | 200 (83.7) | 490 (91.8) | 0.01 |
Other skin lesions* | 63 (26.4) | 124 (23.2) | 0.4 |
Duration (days), median (IQR) | 8 (2–90) | 10 (2–240) | 0.04 |
Joint involvement | 122 (51) | 269 (50.4) | 0.9 |
Gastrointestinal involvement | 91 (38.1) | 207 (38.7) | 0.9 |
Nephropathy | 83 (34.7) | 175 (32.8) | 0.6 |
Mild | 62 (25.9) | 138 (25.8) | 0.9 |
Severe | 21 (8.8) | 30 (5.6) | 0.1 |
Renal insufficiency | 29 (12.1) | 38 (7.1) | 0.02 |
Fever | 57 (23.8) | 125 (23.4) | 0.9 |
Constitutional symptoms | 15 (6.3) | 32 (6.0) | 0.9 |
Laboratory findings | |||
Hemoglobin (g/dl), mean ± SD | 11.9 ± 2.1 | 12 ± 2.3 | 0.8 |
Leukocytes/mm3, mean ± SD | 14,885 ± 3614 | 14,254 ± 3418 | 0.3 |
ESR mm/h, mean ± SD | 49.5 ± 28.1 | 48.5 ± 28.6 | 0.7 |
Abnormal urinalysis, n (%)** | 95 (39.7) | 209 (39.1) | 0.8 |
Any cytopenia, n (%) | 45 (18.8) | 68 (12.7) | 0.03 |
Anemia | 45 (18.8) | 68 (12.7) | 0.03 |
Leukopenia | 12 (5) | 13 (2.4) | 0.06 |
Thrombocytopenia | 3 (1.3) | 12 (2.2) | 0.5 |
Positive ANA, n (%) | 27/128 tested (21.1) | 70/309 tested (22.6) | 0.7 |
Positive RF, n (%) | 22/126 tested (17.5) | 51/282 tested (18.1) | 0.9 |
Positive ANCA, n (%) | 3/65 tested (4.6) | 9/109 tested (8.3) | 0.4 |
Low C3 and/or C4 levels, n (%) | 11/133 tested (8.3) | 38/310 tested (12.2) | 0.2 |
Serum cryoglobulins, n (%) | 19/73 tested (26) | 56/216 tested (25.9) | 0.9 |
↵* Other skin lesions were erythema, bullous, ulcers, or edema.
↵** Abnormal urinalysis refers to the presence of hematuria or proteinuria. IQR: interquartile range; ESR: erythrocyte sedimentation rate, ANA: antinuclear antibodies; RF: rheumatoid factor; ANCA: antineutrophil cytoplasmic antibodies; C3: complement 3; C4: complement 4.