Summary of published literature: differences in disease manifestations between males and females with systemic sclerosis. All values are males (%) vs females (%) unless otherwise specified.
| Study | Myositis | Scleroderma Renal Crisis | PAH | ILD | RP | Serology |
|---|---|---|---|---|---|---|
| Simeon 199653 | 44 vs 6 | 11 vs 9 | 55 vs 72* | NA | NA | NA |
| Al-Dhaher 201024 | NA | 16 vs 6 | 36 vs 28 | 22 vs 13 | NA | ANA-positive, 42 vs 62 |
| Nguyen 201146 | NA | 12.9 vs 8.3 | NA | 54.8 vs 41.2 | 95.2 vs 97.8 | NA |
| Krzyszczak 201156 | Anti-U3 RNP were found only in females | |||||
| White | NA | 8 vs 15 | 23 vs 15 | 46 vs 37 | NA | |
| African | NA | 0 vs 5 | 33 vs 25 | 67 vs 65 | NA | |
| Panopoulos 201355 | NA | 17.4 vs 2.9, p = 0.006 | 18.2 vs 12.6, p = 0.50 | No difference, 45.5 vs 40.7, p = 0.68 | NA | No difference: Scl-70, 66.7 vs 59.3, p = 0.50; ACA, 9.5 vs 22.8, p = 0.17 |
↵* Lung involvement. NA: not available; ANA: antinuclear antibody; ACA: anticentromere antibodies; PAH: pulmonary arterial hypertension; ILD: interstitial lung disease; RP: Raynaud phenomenon; Scl-70: topoisomerase.