Baseline demographic and clinical characteristics of the study cohort.
| Characteristics | Diffuse, n = 517 | Limited, n = 873 | Sine, n = 27 | |||
|---|---|---|---|---|---|---|
| Mean or % | SD or N | Mean or % | SD or N | Mean or % | SD or N | |
| Age, yrs | 53 | 11.7 | 57.1 | 12.3 | 56.4 | 13.6 |
| Female | 78.5 | 406 | 90.2 | 787 | 88.9 | 24 |
| White | 86.1 | 427 | 91.4 | 734 | 96 | 24 |
| Disease duration, yrs | 9 | 8.5 | 11.5 | 9.9 | 11.2 | 8.8 |
| Age at disease onset, yrs | 44 | 13.2 | 45.5 | 13.9 | 44.4 | 14.6 |
| Modified Rodnan skin score | 18.1 | 10.3 | 5.1 | 4.2 | 0 | 0 |
| Raynaud phenomenon | 96.3 | 496 | 97.5 | 849 | 92.6 | 25 |
| Calcinosis | 30.6 | 158 | 25.7 | 224 | 15.4 | 4 |
| Esophageal dysmotility | 70 | 319 | 68.9 | 557 | 56 | 14 |
| Sclerodactyly | 96.3 | 496 | 91.7 | 800 | 0 | 0 |
| Telangiectasias | 71.7 | 352 | 76.4 | 654 | 69.2 | 18 |
| Nailfold capillary abnormalities | 74.4 | 384 | 74.7 | 651 | 74.1 | 20 |
| Digital pits | 54.9 | 282 | 43.6 | 380 | 11.1 | 3 |
| Fingertip ulcers | 58.4 | 302 | 48.1 | 420 | 18.5 | 5 |
| Digital tuft resorption | 46.7 | 237 | 31.7 | 274 | 11.1 | 3 |
| Inflammatory polyarthritis | 37.1 | 185 | 28.1 | 237 | 11.5 | 3 |
| Inflammatory myositis | 15.7 | 81 | 7.7 | 67 | 3.7 | 1 |
| No. GI symptoms, 0–14 | 4.3 | 3 | 4.1 | 3.2 | 3.6 | 3 |
| Malabsorption | 16.6 | 85 | 11.9 | 103 | 0 | 0 |
| Pseudoobstruction | 4.7 | 24 | 3.4 | 29 | 0 | 0 |
| Hyperalimentation | 4.3 | 22 | 1.7 | 15 | 0 | 0 |
| Scleroderma renal crisis | 7.6 | 39 | 1.9 | 16 | 3.7 | 1 |
| Interstitial lung disease | 40.3 | 203 | 25.4 | 218 | 25.9 | 7 |
| Pulmonary hypertension | 10.5 | 46 | 11.1 | 82 | 11.5 | 3 |
| Any overlap disease | 15.6 | 78 | 18.6 | 159 | 4 | 1 |
| Sjögren syndrome | 6.3 | 32 | 8.6 | 74 | 4 | 1 |
| Rheumatoid arthritis | 2.8 | 14 | 4.8 | 41 | 0 | 0 |
| Systemic lupus erythematosus | 3 | 15 | 3.8 | 33 | 0 | 0 |
| Polymyositis/dermatomyositis | 5.3 | 27 | 3 | 26 | 0 | 0 |
| Mixed connective tissue disease | 2.8 | 14 | 2.6 | 22 | 0 | 0 |
GI: gastrointestinal.