Case (ref) | Age, yrs | Sex | Previous Treatments | Thrombopoietin-receptor Agonist | Dose | Response | Time to Response | Adverse Events |
---|---|---|---|---|---|---|---|---|
#1 (PC) | 69 | F | CS, IVIG, splenectomy, RTX | Eltrombopag | 25 mg/day | Yes | 2 weeks | No |
#2 (PC) | 39 | F | CS, IVIG, CYC, azathioprine, RTX | Romiplostim | 2 mcg/kg/week, further increased to 7 μg/kg/week | Yes | 2 weeks | No |
#3 (6) | 44 | M | CS, IVIG, azathioprine, RTX, CYC | Romiplostim | 2 mcg/kg/week | Yes | 3 weeks | No |
#4 (7) | 34 | F | CS, IVIG, RTX, CYC | Romiplostim (previously eltrombopag without response) | 3 mcg/kg/week | Yes | 6 days | No |
#5 (8) | 19 | F | CS, IVIG, RTX | Romiplostim | NS | Yes | NS | Kidney-limited thrombotic microangiopathy |
#6 (9) | 55 | F | CS, RTX, CSA | Eltrombopag | 50 mg/day | Yes | 2 weeks | No |
#7 (10) | NS | NS | NS | NS | NS | No | NS | NS |
PC: present case; CS: corticosteroids; IVIG: intravenous immunoglobulin; RTX: rituximab; CYC: cyclophosphamide; CSA: cyclosporine; NS: not specified.