The use of serological status to predict remission at 24 months using 3-drug therapy (methotrexate, cyclosporine, and prednisolone) compared to methotrexate monotherapy. Adjusted for treatment region, baseline DAS28, sex, and age.
| Predictors of Response | OR | 95% CI | p |
|---|---|---|---|
| RF-IgM–negative | 1.17 | 0.58, 23.9 | NS |
| RF-IgM–positive | 2.54 | 1.12, 5.76 | 0.026 |
| ACPA-negative | 0.91 | 0.19, 4.28 | NS |
| ACPA-positive | 3.52 | 1.37, 9.03 | 0.009 |
DAS28: 28-joint Disease Activity Score; RF-IgM: rheumatoid factor–IgM isotype; ACPA: anticitrullinated protein antibodies; NS: not significant.