APPENDIX 3.

Results using different definitions of structural damage.

		Any BML + Full-thickness Cartilage Loss			Full-thickness Cartilage Loss			Any BML (WORMS > 0)			Large BML (WORMS > 2)
		Sn	Sp	LR+	Sn	Sp	LR+	Sn	Sp	LR+	Sn	Sp	LR+
AKP	Any	68	51	1.4	62	50	1.2	61	53	1.3	62	51	1.3
AKP	Isolated	30	79	1.4	26	81	1.4	28	81	1.5	24	81	1.3
Max pain with stairs (up or down)	(≥ min)	79	32	1.2	79	27	1.1	78	34	1.2	84	27	1.2
Max pain with stairs (up or down)	(≥ mod)	49	69	1.6	38	66	1.1	42	71	1.4	43	66	1.3
Pain going up stairs	(≥ min)	78	34	1.2	75	29	1.1	76	35	1.2	80	30	1.1
Pain going up stairs	(≥ mod)	45	74	1.7	35	70	1.2	37	75	1.5	36	70	1.2
Pain going down stairs	(≥ min)	71	41	1.2	72	37	1.1	68	40	1.1	77	35	1.2
Pain going down stairs	(≥ mod)	41	79	2.0	31	76	1.3	33	81	1.7	37	75	1.5
Absence of pain walking on level ground	(≥ min)	52	42	0.9	58	44	1.0	56	43	1.0	58	45	1.1
Absence of pain walking on level ground	(≥ mod)	93	11	1.0	93	12	1.1	92	12	1.0	89	11	1.0
Any AKP + max pain with stairs	(≥ min)	61	63	1.6	55	62	1.4	51	63	1.4	57	60	1.4
Any AKP + max pain with stairs	(≥ mod)	41	82	2.3	29	80	1.5	29	83	1.7	29	80	1.5
Any AKP + absence of pain walking on level ground	(≥ min)	30	74	1.2	33	74	1.3	30	75	1.2	33	75	1.3
Any AKP + absence of pain walking on level ground	(≥ mod)	62	57	1.4	57	57	1.3	55	60	1.4	54	57	1.3
Isolated AKP + max pain with stairs	(≥ min)	25	88	2.1	22	88	1.8	21	89	1.9	21	87	1.6
Isolated AKP + max pain with stairs	(≥ mod)	14	96	3.5	9	96	2.3	9	97	3.0	9	96	2.3
Isolated AKP + absence of pain walking on level ground	(≥ min)	21	85	1.4	20	86	1.4	20	87	1.5	18	86	1.3
Isolated AKP + absence of pain walking on level ground	(≥ mod)	28	80	1.4	25	82	1.4	26	82	1.4	22	81	1.2