Predictive value of achieving remission at 24 months using 3-drug therapy (methotrexate, cyclosporine, and prednisolone) compared to methotrexate monotherapy, adjusted for treatment region.
| Predictors of Response | OR | 95% CI | p |
|---|---|---|---|
| Female | 1.80 | 0.68–4.78 | NS |
| Male | 2.99 | 1.01–8.90 | 0.049 |
| Over 50 years old | 4.95 | 1.66–14.75 | 0.004 |
| Under 50 years old | 1.09 | 0.38–3.16 | NS |
| ≥ 6 TJC | 1.56 | 0.43–5.63 | NS |
| < 6 TJC | 2.71 | 1.11–6.60 | 0.028 |
| RF-IgM–negative | 1.49 | 0.17, 12.46 | NS |
| RF-IgM–positive | 2.28 | 1.08, 4.85 | 0.032 |
| ACPA-negative | 1.03 | 0.25, 4.30 | NS |
| ACPA-positive | 2.99 | 1.29, 6.97 | 0.011 |
RF-IgM: rheumatoid factor–IgM isotype; ACPA: anticitrullinated protein antibodies; TJC: tender joint count; NS: not significant.