Comparison of clinical findings and renal history between groups A and B. Data are n (%) or mean ± SD; Fisher’s exact test, chi-square test, Mann-Whitney U test.
| Characteristics | Group A, n = 10 | Group B, n = 40 | p |
|---|---|---|---|
| Age, yrs | 67.6 ± 9.05 | 61.4 ± 15.5 | NS |
| Sex, men/women | 3/7 | 11/29 | NS |
| Duration of disease, mos | 57.7 ± 57.6 | 78.8 ± 63.0 | NS |
| MPO-ANCA positive | 8 (80) | 42 (95.4) | NS |
| PR3-ANCA positive | 2 (20) | 3 (6.7) | NS |
| MPO-ANCA (EU) | 377.0 ± 294.1 | 272.0 ± 336.7 | NS |
| PR3-ANCA (EU) | 70.0 ± 84.9 | 59.3 ± 51.9 | NS |
| C-reactive protein, mg/dl | 11.58 ± 6.19 | 2.7 ± 3.55 | < 0.01 |
| Creatinine (mg/dl) | 3.8 ± 3.2 | 3.7 ± 3.0 | NS |
| Urine protein, g/day | 0.94 ± 0.65 | 2.08 ± 2.25 | NS |
| Hematuria, > 6/HPF | 9 (90) | 40 (100) | NS |
| Glomerular lesions; crescents (%) | 41.1 ± 29.6 | 42.9 ± 29.4 | NS |
| Glomerular sclerosis (%) | 15.0 ± 15.7 | 35.0 ± 29.1 | 0.042 |
| Fibrinoid necrosis | 6 (60) | 16 (40) | NS |
| Pulmonary involvement | 8 (80) | 15 (37.5) | 0.016 |
| Others (neuron, ear, skin) | 4 (40) | 7 (17.5) | NS |
| GPA (patients) | 4 (40) | 1 (2.5) | < 0.05 |
| MPA (RLV) | n = 6 (n = 2) | n = 39 (n = 21) | — |
HPF: high-power field; MPO: myeloperoxidase; ANCA: antineutrophil cytoplasmic antibody; PR3: proteinase 3; GPA: granulomatosis with polyangiitis; MPA: microscopic polyangiitis; RLV: renal-limited AAV; AAV: ANCA-associated vasculitis; NS: not significant.