Tophaceous Gout Cases vs Nontophaceous Gout Cases | ||
---|---|---|
Adjusted OR (95% CI) | p | |
Taiwanese Han | ||
rs2231142 Q141K | ||
G/G | 1.00 | |
G/T | 1.31 (0.59–2.88) | 5.09 × 10–1 |
T/T | 2.04 (0.92–4.54) | 8.01 × 10–2 |
G-allele | 1.00 | |
T-allele | 1.51 (1.00–2.28) | 5.02 × 10–2 |
Taiwan Aborigines | ||
rs2231142 Q141K | ||
G/G | 1.00 | |
G/T | 1.65 (1.01–2.68) | 4.36 × 10–2 |
T/T | 2.12 (1.28–3.52) | 3.60 × 10–2 |
G-allele | 1.00 | |
T-allele | 1.50 (1.16–1.94) | 2.31 × 10–3 |
Pooled analysis | ||
rs2231142 Q141K | ||
G/G | 1.00 | |
G/T | 1.61 (1.07–2.42) | 2.18 × 10–2 |
T/T | 2.21 (1.45–3.37) | 2.20 × 10–4 |
G-allele | 1.00 | |
T-allele | 1.55 (1.25–1.92) | 7.84 × 10–5 |
Adjusted OR and their p values were adjusted for sex, body mass index, log (triglycerides), creatinine, diabetes mellitus, and alcohol use, and for the pooled analysis, ethnicity, using a multiple logistic regression model. Pooled analysis was performed by the Cochran-Mantel-Haenszel test method using the PLINK v1.07. Single-nucleotide polymorphism rs2231142 Q141K revealed evidence of homogeneity in the association with tophaceous gout (p Breslow-Day test = 0.85).