Variable | Group 1 (no-MDA), n = 76 | Group 2 (MDA), n = 80 | p |
---|---|---|---|
Age, yrs | 45.73 ± 12.35 | 46.65 ± 11.57 | 0.634 |
Male sex, n (%) | 36 (47.4) | 32 (40.0) | 0.420 |
PAI-1 antigen | 67.28 ± 13.94 | 58.62 ± 11.14 | 0.032 |
t-PA levels | 9.45 ± 2.22 | 8.07 ± 1.61 | 0.027 |
PAI-1/t-PA ratio | 7.11 ± 5.56 | 7.26 ± 4.87 | 1.000 |
Fibrinogen | 328.57 ± 83.05 | 302.12 ± 43.19 | 0.031 |
D-dimer | 252.12 ± 252.12 | 190.47 ± 73.19 | 0.045 |
FVII | 123.92 ± 20.43 | 107.70 ± 12.18 | < 0.001 |
FVIII | 129.01 ± 25.24 | 119.33 ± 17.42 | 0.008 |
vWF | 138.11 ± 28.41 | 128.98 ± 19.96 | 0.029 |
Prot C | 121.47 ± 18.25 | 114.25 ± 14.81 | 0.039 |
Prot S | 114.57 ± 23.12 | 106.11 ± 15.29 | 0.013 |
AT | 100.43 ± 7.62 | 96.36 ± 5.96 | 0.006 |
ESR | 22.40 ± 13.46 | 18.17 ± 8.98 | 0.032 |
CRP | 5.02 ± 5.83 | 3.46 ± 2.20 | 0.034 |
Clinical subset, n (%) | |||
Axial + peripheral | 25 (32.9) | 29 (36.2) | 0.596 |
Peripheral | 27 (35.5) | 26 (32.5) | 0.693 |
Axial | 18 (23.7) | 19 (23.8) | 1.000 |
Mutilans | 6 (7.9) | 6 (7.5) | 0.780 |
Disease duration (mos) | 126.93 ± 58.83 | 101.72 ± 74.01 | 0.004 |
SJC | 3.39 ± 4.69 | 1.82 ± 2.03 | 0.013 |
TJC | 14.72 ± 9.99 | 7.45 ± 5.58 | < 0.001 |
PASI | 1.45 ± 0.76 | 1.49 ± 0.68 | 0.700 |
HAQ | 2.31 ± 0.52 | 1.20 ± 1.12 | 0.001 |
VAS | 44.3 ± 21.6 | 22.9 ± 18.1 | < 0.001 |
Patient global VAS | 51.4 ± 23.7 | 23.3 ± 15.1 | < 0.001 |
Tender entheseal count | 9.66 ± 5.06 | 11.71 ± 5.45 | 0.003 |
Hypercholesterolemia, n (%) | 38 (50.0) | 47 (58.8) | 0.335 |
Hypertriglyceridemia, n (%) | 25 (32.9) | 27 (33.8) | 1.000 |
Impaired fasting glucose, n (%) | 7 (9.2) | 5 (6.3) | 0.557 |
Hypertension, n (%) | 14 (18.4) | 18 (22.5) | 0.558 |
Smoking habit, n (%) | 22 (28.9) | 17 (21.3) | 0.275 |
Obesity, n (%) | 32 (42.1) | 37 (46.3) | 0.631 |
MDA: minimal disease activity; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; SJC: swollen joint count; TJC: tender joint count; PASI: psoriasis area severity index; HAQ: Health Assessment Questionnaire; VAS: visual analog scale for pain; PAI-1: plasminogen activator inhibitor-1; t-PA: tissue plasminogen activator; FVII: coagulation factor VII; FVIII: coagulation factor VIII; vWF: von Willebrand factor; AT: antithrombin; Prot C: protein C; Prot S: protein S.