A | Vignette 1 | Vignette 2 | Vignette 3* | ||||
---|---|---|---|---|---|---|---|
Accept TX (%) | OR (95% CI) | Accept TX (%) | OR (95% CI) | Accept TX (%) | OR (95% CI) | ||
10-year personal fracture risk estimate† | —‡ | 1.01 (1.00, 1.02) | — | 1.02 (1.00, 1.03) | — | 1.02 (1.01, 1.03) | |
Personal osteoporosis diagnosis | Yes | 64.2 | 2.66 (1.35, 5.23) | 62.3 | 2.23 (1.14, 4.36) | 71.7 | 2.9 (1.4, 5.9) |
No | 37.5 | — | 40.2 | — | 45.1 | — | |
High numeracy§ | Yes | 32.6 | 0.46 (0.25, 0.82) | 37.9 | 0.63 (0.35, 1.11) | 45.0 | 0.7 (0.4, 1.2) |
No | 52.9 | — | 52.0 | — | 57.0 | — | |
Pharmacologic treatments worth the risks | Yes | 47.4 | 1.8 (0.9, 3.5) | 49.1 | 1.9 (0.97, 3.67) | 56.6 | 2.3 (1.2, 4.4) |
No | 32.8 | — | 34.43 | — | 36.6 | — |
B | Vignette 4 | Vignette 5 | Vignette 6 | ||||
---|---|---|---|---|---|---|---|
Accept TX (%) | OR (95% CI) | Accept TX (%) | OR (95% CI) | Accept TX (%) | OR (95% CI) | ||
10-year personal fracture risk estimate† | —‡ | 1.01 (1.00, 1.02) | — | 1.01 (1.00, 1.03) | — | 1.02 (1.00, 1.03) | |
Personal osteoporosis diagnosis | Yes | 73.6 | 1.4 (0.7, 3.0) | 83.0 | 1.67 (0.71, 3.93) | 79.3 | 0.83 (0.35, 1.96) |
No | 64.3 | — | 75.4 | — | 83.0 | — | |
High numeracy§ | Yes | 64.0 | 0.8 (0.4, 1.5) | 78.7 | 1.34 (0.67, 2.66) | 86.2 | 1.93 (0.87, 4.27) |
No | 70.0 | — | 75.6 | — | 78.7 | — | |
Pharmacologic treatments worth the risks | Yes | 74.0 | 3.4 (1.8, 6.5) | 83.3 | 3.23 (1.61, 6.50) | 88.4 | 4.08 (1.91, 8.72) |
No | 45.6 | — | 60.7 | — | 65.6 | — |
↵* Vignette 3 is at, and vignette 4 is just above, current physician thresholds. Vignette 3 asked the subject to imagine that she was a 70-year-old woman whose risk of a broken hip in the next 10 years was 3% and risk of other fractures was 12%. Vignette 4 asked the same, but for hip fracture risk of 6% and other fracture risk of 24%. All risks were based on a validated algorithm23 and are similar to recent estimates using the World Health Organization’s FRAX risk assessment algorithm.
↵† 1% increase in absolute 10-year fracture estimate.
↵‡ All “—” indicated the comparison case.
↵§ Score of 2–3 on numeracy scale.