Comparison of JIA and JIA-U among African American and non-Hispanic white children. Data are n (%) unless otherwise indicated.
| All JIA, n = 3967 | JIA-U, n = 459 | JIA Alone, n = 3508 | p** | |
|---|---|---|---|---|
| Demographic Characteristics | ||||
| Age at time of study, yrs, mean ± SD | 11.4 ± 4.7 | 11.1 ± 4.5 | 11.5 ± 4.7 | 0.096 |
| Sex, female | 2857 (72.0) | 353 (76.9) | 2504 (71.4) | 0.013* |
| Race | 0.010* | |||
| Non-Hispanic white | 3747 (94.5) | 446 (97.2) | 3301 (94.1) | |
| African American | 220 (5.6) | 13 (2.8) | 207 (5.9) | |
| Disease Characteristics | ||||
| Age at arthritis onset, yrs ± SD | 6.4 ± 4.4 | 4.2 ± 3.6 | 6.7 ± 4.5 | < 0.001* |
| JIA subtype | < 0.001* | |||
| Systemic | 295 (7.5) | 2 (0.4) | 293 (8.4) | < 0.001* |
| Polyarticular RF-negative | 1188 (30.3) | 109 (24.2) | 1079 (31.1) | 0.003* |
| Polyarticular RF-positive | 214 (5.5) | 3 (0.7) | 211 (6.1) | < 0.001* |
| Oligoarticular persistent | 1140 (29.1) | 191 (42.4) | 949 (27.4) | < 0.001* |
| Oligoarticular extended | 321 (8.2) | 66 (14.7) | 255 (7.4) | < 0.001* |
| Psoriatic | 251 (6.4) | 31 (6.9) | 220 (6.3) | 0.655 |
| Enthesitis-related | 416 (10.6) | 34 (7.6) | 382 (11.0) | 0.025* |
| Undifferentiated | 95 (2.4) | 14 (3.1) | 81 (2.3) | 0.313 |
| Laboratory measures | ||||
| ANA-positive, n = 3525 | 1736 (49.3) | 270 (65.4) | 1466 (47.1) | < 0.001* |
| RF-positive, n = 1414 | 129 (9.1) | 2 (1.4) | 127 (10.0) | 0.001* |
| HLA-B27–positive, n = 2165 | 324 (15.0) | 47 (19.0) | 277 (14.4) | 0.057 |
| ACPA-positive, n = 1524 | 145 (9.5) | 4 (2.9) | 141 (10.2) | 0.006* |
| QOL Measures, mean ± SD | ||||
| Physician global assessment | 1.6 ± 1.9 | 1.3 ± 1.7 | 1.6 ± 2.0 | < 0.001* |
| CHAQ | 0.36 ± 0.60 | 0.26 ± 0.50 | 0.37 ± 0.61 | < 0.001* |
| Patient/parent pain scale score | 2.6 ± 2.6 | 2.0 ± 2.5 | 2.7 ± 2.7 | < 0.001* |
| Patient/parent overall well-being score | 2.3 ± 2.3 | 1.9 ± 2.1 | 2.4 ± 2.3 | < 0.001* |
| Health-related QOL | 0.271 | |||
| Excellent | 957 (24.4) | 124 (27.4) | 833 (24.0) | |
| Very good | 1642 (41.9) | 193 (42.7) | 1449 (41.8) | |
| Good | 1196 (30.5) | 119 (26.3) | 1077 (31.1) | |
| Poor | 116 (3.0) | 15 (3.3) | 101 (2.9) | |
| Very poor | 10 (0.3) | 1 (0.2) | 9 (0.3) | |
| Parent/subject assessment of disease activity | 2.6 ± 2.7 | 2.1 ± 2.6 | 2.6 ± 2.7 | < 0.001* |
↵* p < 0.05; chi-squared, 2-sample or Wilcoxon rank-sum tests;
a Higher scores indicate worse disease;
↵** p value based on comparison of JIA-U vs JIA alone. CHAQ: Childhood Health Assessment Questionnaire; JIA: juvenile idiopathic arthritis; JIA-U: JIA-associated uveitis; RF: rheumatoid factor; ANA: antinuclear antibody; ACPA: anticitrullinated protein antibodies; QOL: quality of life.