Novel future severe organ involvement [9 organ systems according to the Medsger disease severity scale and lung subdefined into interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH)] in the Italian-Belgian (n = 148) cohort.
| Organ Systems | Not Novel Severe | Novel Severe | Total | p+ |
|---|---|---|---|---|
| General | 132 | 5 | 137‡ | 0.13¶ |
| Peripheral vascular | 121 | 19 | 140§ | 0.02* |
| Skin | 133 | 7 | 140§ | 0.12¶ |
| Joint | 132 | 7 | 139** | 0.12¶ |
| Muscle | 135 | 4 | 139** | 0.35¶ |
| GI tract | 131 | 6 | 137‡ | 0.63¶ |
| Lung | 122 | 15 | 137‡ | 0.49 |
| ILD | 131 | 6 | 137‡ | 0.71¶ |
| PAH | 134 | 3 | 137‡ | 0.42¶ |
| Heart | 134 | 5 | 139** | 0.10¶ |
| Kidney | 136 | 2 | 138†† | 0.23¶ |
| In any of the 9 organ systems | 78 | 56 | 134† | < 0.001* |
↵+ Likelihood ratio p-value based on logistic regression analysis with a dichotomous outcome measure of severity of future organ involvement associated with continuous baseline nailfold videocapillaroscopy (NVC) patterns, unless too few events were present to support a linear effect on the natural logarithm of the OR [1n(OR)].
↵¶ In the latter cases, the LRT p-values of a categorical NVC pattern covariate were reported.
↵† Insufficient followup data were available for 14 patients.
↵‡ Insufficient followup data were available for 11 patients.
↵§ Insufficient followup data were available for 8 patients.
↵** Insufficient followup data were available for 9 patients.
↵†† Insufficient followup data were available for 10 patients.
↵* Statistically significant if p < 0.05. Future visit at 18–24 months after the baseline capillaroscopic assessment. Novel severe category 2–4 of the Medsger disease severity scale or PAH or ILD that were not present at the baseline visit.