Outcome measures used in the study.
| Outcome Measures | Formula/definition |
|---|---|
| Standard | |
| DAS28-ESR3 | [0.56*sqrt(Tender) + 0.28*sqrt(Swollen) + 0.70*ln(ESR)]*1.08 + 0.16 |
| DAS28-ESR4 | 0.56*sqrt(Tender) + 0.28*sqrt(Swollen) + 0.70*ln(ESR) + 0.014*(VAS) |
| DAS28-CRP3 | [0.56*sqrt(Tender) + 0.28*sqrt(Swollen) + 0.36*ln(CRP+1)]*1.10 + 1.15 |
| DAS28-CRP4 | 0.56*sqrt(Tender) + 0.28*sqrt(Swollen) + 0.36*ln(CRP+1) + 0.014*(VAS) + 0.96 |
| Hensor, et al37 | |
| Unadjusteda DAS28-CRP4 | 0.56*sqrt(Tender) + 0.28*sqrt(Swollen) + 0.292*ln(CRP+1) + 0.014*(VAS) + 1.523 |
| Adjustedb DAS28-CRP4 | 0.56*sqrt(Tender) + 0.28*sqrt(Swollen) + 0.288*ln(CRP+1) + 0.014*(VAS) + 0.003*(Age) + 0.159 (if female) + 1.238 |
| Current study data-specific | |
| Unadjusteda DAS28-CRP4 | 0.56*sqrt(Tender) + 0.28*sqrt(Swollen) + 0.1918*ln(CRP+1) + 0.014*(VAS) + 2.086 |
| Adjustedb DAS28-CRP4 | 0.56*sqrt(Tender) + 0.28*sqrt(Swollen) + 0.1878*ln(CRP+1) + 0.014*(VAS) + 0.0073*(Age) + 0.2501 (if female) + 1.49843 |
↵a Unadjusted for age and sex.
↵b Adjusted for age and sex. DAS: disease activity score; ESR: erythrocyte sedimentation rate; Tender: 28 tender joint count; Swollen: 28 swollen joint count; CRP: C-reactive protein, high sensitivity; VAS: visual analog scale, self-assessed patient global assessment of disease activity on a VAS of 0 to 100 mm.