Covariate | CDAI | HAQ-DI | ||
---|---|---|---|---|
Adjusted HR (95% CI) | p | Adjusted HR (95% CI) | p | |
CDAI | ||||
Low disease activity | 2.715 (1.178–6.258) | 0.0191 | NA | NA |
Moderate disease activity | 4.261 (1.870–9.710) | 0.0006 | NA | NA |
High disease activity | 4.800 (2.110–10.924) | 0.0002 | NA | NA |
HAQ-DI | ||||
0.5–1.0 | NA | NA | 1.700 (1.119–2.584) | 0.0129 |
> 1.0–2.0 | NA | NA | 2.508 (1.731–3.633) | < 0.0001 |
> 2.0–3.0 | NA | NA | 4.462 (2.990–6.657) | < 0.0001 |
Disease duration | 1.019 (1.009–1.030) | 0.0003 | 1.014 (1.003–1.024) | 0.0112 |
Age at disease onset ≥ 65 yrs | 1.289 (0.930–1.785) | 0.1269 | 1.217 (0.879–1.685) | 0.2364 |
Comorbid asthma or COPD | 1.925 (1.479–2.505) | < 0.0001 | 1.767 (1.358–2.298) | < 0.0001 |
Extraarticular manifestations* | 1.464 (1.147–1.868) | 0.0022 | 1.444 (1.132–1.841) | 0.0031 |
Comorbid conditions† | 2.388 (1.662–3.430) | < 0.0001 | 2.395 (1.671–3.434) | < 0.0001 |
Oral corticosteroid dose | ||||
< 5 mg/day | 1.599 (1.082–2.362) | 0.0184 | 1.680 (1.142–2.471) | 0.0084 |
5–10 mg/day | 1.688 (1.277–2.232) | 0.0002 | 1.655 (1.252–2.188) | 0.0004 |
≥ 10 mg/day | 2.835 (2.146–3.746) | < 0.0001 | 2.702 (2.047–3.565) | < 0.0001 |
Nonbiologic DMARD†† | 1.071 (0.810–1.417) | 0.6301 | 1.095 (0.828–1.448) | 0.5258 |
Nonbiologic DMARD# | 0.912 (0.716–1.162) | 0.4545 | 0.947 (0.744–1.205) | 0.6589 |
Biologic DMARD | 1.125 (0.897–1.411) | 0.3070 | 1.080 (0.861–1.354) | 0.5057 |
Previous hospitalization due to infection | 2.284 (1.661–3.138) | < 0.0001 | 2.044 (1.486–2.811) | < 0.0001 |
↵* Classified as associated with RA.
↵† Classified as not associated with RA.
↵†† Classified as posing a significant infection risk.
↵# Classified as not posing a significant infection risk. CDAI: Clinical Disease Activity Index; COPD: chronic obstructive pulmonary disease; DMARD: disease-modifying antirheumatic drug; HAQ-DI: Health Assessment Questionnaire-Disability Index; NA: not applicable; RA: rheumatoid arthritis; SIE: serious infection event.