12 Months | 24 Months | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Characteristic | All | n | RF− | n | RF+ | n | p | All | n | RF− | n | RF+ | n | p |
SJC28, median (range) | 1 (0–24) | 514 | 0 (0–24) | 244 | 1 (0–12) | 270 | NS | 0 (0–17) | 361 | 0 (0–17) | 174 | 0 (0–16) | 187 | NS |
TJC28, median (range) | 1 (0–25) | 514 | 1 (0–25) | 244 | 1 (0–19) | 270 | NS | 0 (0–23) | 361 | 0 (0–23) | 174 | 0 (0–23) | 187 | NS |
ESR, mean (SD) | 14.49 (14.88) | 510 | 11.72 (11.35) | 244 | 17.03 (17.14) | 266 | < 0.0001 | 14.98 (14) | 367 | 12.89 (12.69) | 178 | 16.94 (14.9) | 189 | 0.0055 |
CRP, mean (SD), mg/l | 5.24 (7.91) | 508 | 4.21 (6.81) | 245 | 6.19 (8.72) | 263 | 0.0045 | 5.47 (8.56) | 367 | 4.62 (6.8) | 177 | 6.27 (9.88) | 190 | NS |
Erosions | 87 (27) | 322 | 39 (25.7) | 152 | 48 (28.2) | 170 | NS | 66 (26.7) | 247 | 28 (24.1) | 116 | 38 (29) | 131 | NS |
DAS28, mean (SD) | 2.79 (1.29) | 493 | 2.63 (1.22) | 230 | 2.94 (1.34) | 263 | 0.0093 | 2.71 (1.35) | 347 | 2.58 (1.31) | 166 | 2.82 (1.38) | 181 | NS |
DAS28 < 2.6 | 272 (52.3) | 520 | 145 (58) | 250 | 127 (47) | 270 | 0.0124 | 221 (58.8) | 376 | 113 (62.1) | 182 | 108 (55.7) | 194 | NS |
HAQ, median (range) | 0.25 (0–3) | 502 | 0.25 (0–2.38) | 241 | 0.25 (0–3) | 261 | NS | 0.25 (0–2.5) | 355 | 0.25 (0–2.5) | 168 | 0.25 (0–2.38) | 187 | NS |
RF-positive | 270 (51.9) | 520 | — | — | — | — | — | 194 (51.6) | 376 | — | — | — | — | — |
Anti-CCP2-positive | 203 (62.3) | 326 | 69 (45.4) | 152 | 134 (77) | 174 | < 0.0001 | 150 (60.5) | 248 | 59 (47.6) | 124 | 91 (73.7) | 124 | < 0.0001 |
1987 ACR RA criteria | 334 (65.4) | 511 | 142 (58.4) | 243 | 192 (71.6) | 268 | 0.0017 | 242 (64.9) | 373 | 111 (61.3) | 181 | 131 (68.2) | 192 | NS |
2010 ACR/EULAR RA criteria | 373 (71.7) | 520 | 160 (64) | 250 | 213 (78.9) | 270 | 0.0002 | 278 (73.9) | 376 | 123 (67.6) | 182 | 155 (79.9) | 194 | 0.0066 |
DMARD | 481 (93.6) | 514 | 231 (94.7) | 244 | 250 (92.6) | 270 | NS | 347 (93) | 373 | 171 (95) | 180 | 176 (91.2) | 193 | NS |
Biologics | 50 (9.7) | 514 | 29 (11.9) | 244 | 21 (7.8) | 270 | NS | 55 (14.8) | 373 | 37 (20.6) | 180 | 18 (9.3) | 193 | 0.0022 |
Corticosteroids | 122 (23.7) | 514 | 56 (23) | 244 | 66 (24.4) | 270 | NS | 94 (25.2) | 373 | 38 (21.1) | 180 | 56 (29) | 193 | NS |
Anti-CCP: anticyclic citrullinated peptide; RF: rheumatoid factor; SJC28: swollen joint count-28; TJC28: tender joint count-28; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; DAS28: Disease Activity Score-28; ACR: American College of Rheumatology; EULAR: European League Against Rheumatism; DMARD: disease-modifying antirheumatic drugs; NS: nonsignificant; HAQ: Health Assessment Questionnaire; RA: rheumatoid arthritis.