SIE hazard estimates at different severity levels of disease controlling for all other variables, using CDIA and HAQ-DI as measures of disease activity.
| Covariate | Adjusted HR (95% CI) | p |
|---|---|---|
| CDAI | ||
| Low disease activity | 2.093 (0.898–4.878) | 0.0869 |
| Moderate disease activity | 2.740 (1.177–6.380) | 0.0194 |
| High disease activity | 2.685 (1.147–6.285) | 0.0229 |
| HAQ-DI | ||
| 0.5–1.0 | 1.511 (0.983–2.322) | 0.0598 |
| > 1.0–2.0 | 2.066 (1.392–3.065) | 0.0003 |
| > 2.0–3.0 | 3.638 (2.366–5.594) | < 0.0001 |
| Disease duration | 1.013 (1.003–1.024) | 0.0140 |
| Age at disease onset ≥ 65 yrs | 1.253 (0.904–1.736) | 0.1759 |
| Comorbid asthma or COPD | 1.779 (1.365–2.317) | < 0.0001 |
| Extraarticular manifestations* | 1.435 (1.124–1.833) | 0.0038 |
| Comorbid conditions† | 2.378 (1.658–3.413) | < 0.0001 |
| Oral corticosteroid dose | ||
| < 5 mg/day | 1.634 (1.105–2.415) | 0.0138 |
| 5–10 mg/day | 1.615 (1.220–2.138) | 0.0008 |
| ≥ 10 mg/day | 2.626 (1.984–3.476) | < 0.0001 |
| Nonbiologic DMARD†† | 1.091 (0.824–1.443) | 0.5443 |
| Nonbiologic DMARD# | 0.932 (0.731–1.187) | 0.5673 |
| Biologic DMARD | 1.080 (0.861–1.356) | 0.5043 |
| Previous hospitalization due to infection | 2.049 (1.488–2.823) | < 0.0001 |
↵* Classified as associated with RA.
↵† Classified as not associated with RA.
↵†† Classified as posing a significant infection risk.
↵# Classified as not posing a significant infection risk. CDAI: Clinical Disease Activity Index; COPD: chronic obstructive pulmonary disease; DMARD: disease-modifying antirheumatic drug; HAQ-DI: Health Assessment Questionnaire-Disability Index; RA: rheumatoid arthritis; SIE: serious infection event.