SIE hazard estimates controlling for all other variables, using CDAI and HAQ-DI as measures of disease activity.
| Covariate | Adjusted HR (95% CI) | p |
|---|---|---|
| CDAI, 5 unit | 1.020 (0.984–1.056) | 0.2803 |
| HAQ-DI, 0.4 unit | 1.285 (1.204–1.372) | < 0.0001 |
| Disease duration | 1.012 (1.002–1.023) | 0.0245 |
| Age at disease onset ≥ 65 yrs | 1.244 (0.897–1.725) | 0.1900 |
| Comorbid asthma or COPD | 1.741 (1.336–2.268) | < 0.0001 |
| Extraarticular manifestations* | 1.423 (1.113–1.818) | 0.0049 |
| Comorbid conditions† | 2.398 (1.672–3.439) | < 0.0001 |
| Oral corticosteroid dose | ||
| < 5 mg/day | 1.653 (1.118–2.444) | 0.0117 |
| 5–10 mg/day | 1.598 (1.206–2.116) | 0.0011 |
| ≥ 10 mg/day | 2.535 (1.912–3.361) | < 0.0001 |
| Nonbiologic DMARD†† | 1.093 (0.826–1.446) | 0.5342 |
| Nonbiologic DMARD# | 0.949 (0.745–1.209) | 0.6731 |
| Biologic DMARD | 1.083 (0.863–1.358) | 0.4912 |
| Previous hospitalization due to infection | 1.977 (1.433–2.727) | < 0.0001 |
↵* Classified as associated with RA.
↵† Classified as not associated with RA.
↵†† Classified as posing a significant infection risk.
↵# Classified as not posing a significant infection risk. CDAI: Clinical Disease Activity Index; COPD: chronic obstructive pulmonary disease; DMARD: disease-modifying antirheumatic drug; HAQ-DI: Health Assessment Questionnaire-Disability Index; RA: rheumatoid arthritis; SIE: serious infection event.