SNP with the most significant association with SLE.
| MAF | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| SNP | Chr | Pos (Mb) | Region | Risk Allele | Case | Control | Best-P* | P-GC | OR (95% CI)* |
| African (AA + Gullah) | |||||||||
| rs2551715 | 8 | 30,666 | GSR | A | 0.30 | 0.27 | 4.57E-03d | 6.43E-03 | 1.21 (1.06–1.38) |
| rs2253409 | 8 | 30,667 | GSR | G | 0.33 | 0.30 | 7.21E-04d | 1.16E-03 | 1.26 (1.10–1.44) |
| AA | |||||||||
| rs2253409 | 8 | 30,667 | GSR | G | 0.33 | 0.30 | 1.43E-03d | 3.43E-03 | 1.26 (1.09–1.44) |
| Gullah | |||||||||
| rs381575 | 5 | 52,949 | NDUFS4 | C | 0.62 | 0.55 | 6.51E-03r | — | 2.10 (1.23–3.59) |
| rs561712 | 12 | 116,236 | NOS1 | A | 0.38 | 0.51 | 7.18E-03a | — | 0.62 (0.44–0.88) |
| rs3730013 | 17 | 23,150 | NOS2A | A | 0.22 | 0.33 | 1.74E-03d | — | 0.46 (0.28–0.75) |
↵* Best-P, OR, and CI reported under the following genetic models:
↵a additive,
↵d dominant,
↵r recessive. Chr: chromosome; Pos: position; MAF: minor allele frequency; P-GC: best-P after a genomic control adjustment; SNP: single-nucleotide polymorphism; AA: African American; GSR: glutathione reductase; NDUF: nicotinamide adenin dinucleoacid hydrogen; NOS: nitric oxide synthase; SLE: systemic lupus erythematosus.