Adult-onset: 1989 to 20045; 1995 to 20026 | Childhood-onset: 1951 to 20079, Cases 1995–201210–14, This Series | p | |
---|---|---|---|
Type of Study | Multicenter retrospective | Case series retrospective | |
No. | 205 | 47 | |
Age, mean yrs | 48 | 12 | |
Male/female ratio | 0.87:1 | 0.36:1 | < 0.001 |
Eosinophilia | Present | Present | |
ANCA (% positive) | 78/205 (38) | 6/24 (25) | 0.066 |
Clinical features (%) | |||
Asthma | 200/205 (98) | 43/47 (91) | NS |
Sinusitis | 139/205 (77) | 30/41 (75) | NS |
Lung | 120/205 (59) | 43/47 (91) | < 0.001 |
Pulmonary infiltrates | 73/112 (65) | 39/47 (83) | 0.02 |
Pleural effusion | 25/112 (22) | 7/47 (15) | NS |
Heart | 54/205 (26) | 21/47 (45) | 0.01 |
Pericarditis | 28/112 (25) | 12/47 (26) | NS |
Cardiomyopathy | 27/112 (24) | 16/47 (34) | NS |
Mitral valve insufficiency | Not erported | 6/47 (13) | — |
Musculoskeletal | |||
Arthralgia | 42/112 (37) | 12/45 (27) | NS |
Myalgia | 60/112 (54) | 10/45 (22) | 0.001 |
Skin | 107/205 (52) | 31/46 (67) | 0.11 |
Peripheral nervous system | 141/205 (69) | 18/45 (40) | < 0.001 |
Gastrointestinal involvement | 56/205 (27) | 22/47 (47) | 0.02 |
Renal | 43/205 (21) | 6/46 (13) | NS |
Biopsy findings (%) | |||
Vasculitis | 53/95 (56) | 29/43 (67) | NS |
Extravascular eosinophilia | 50/95 (53) | 35/43 (81) | 0.001 |
Granuloma | 17/95 (18) | 13/43 (30) | 0.10 |
Deaths | 6/112 (5) | 6/47 (13) | 0.10 |
ANCA: Antineutrophil cytoplasmic antibody; NS: nonsignificant.