Predictors of time to all-cause mortality, using multivariate Cox regression.
| Variable | HR (95% CI) | p |
|---|---|---|
| MTHFR A1298C* (rs1801131) | ||
| AA | ref | |
| AC | 0.98 (0.74, 1.32) | 0.916 |
| CC | 0.92 (0.58, 1.45) | 0.717 |
| MTHFR C677T* (rs1801133) | ||
| CC | ref | |
| CT | 0.85 (0.64, 1.14) | 0.280 |
| TT | 0.87 (0.52, 1.44) | 0.578 |
| Age | 1.08 (1.06, 1.09) | < 0.0001 |
| Methotrexate use | 0.75 (0.58, 0.97) | 0.027 |
| Body mass index | 0.96 (0.93, 0.98) | 0.002 |
| Modified Charlson-Deyo index | 1.13 (1.07, 1.20) | < 0.0001 |
| Heart failure | 1.52 (1.13, 2.06) | 0.006 |
| DAS28 | 1.38 (1.23, 1.55) | < 0.0001 |
| CRP | 1.01 (1.00, 1.01) | 0.011 |
| Smoking status | ||
| Never | ref | |
| Former | 1.35 (0.94, 1.93) | 0.100 |
| Current | 1.93 (1.26, 2.96) | 0.003 |
↵* Polymorphisms are listed in order of major allele homozygous, heterozygous, minor allele homozygous. MTHFR: methylenetetrahydrofolate reductase; ref: referent; DAS28: 4-variable Disease Activity Score using 28-joint count and erythrocyte sedimentation rate; CRP: C-reactive protein.