Predictors of time to CV event, excluding those with prior CV events, using multivariate Cox regression.
| Variable | HR (95% CI) | p |
|---|---|---|
| MTHFR A1298C; ≥ 1 copy minor allele | 1.28 (0.71, 2.32) | 0.414 |
| MTHFR C677T; ≥ 1 copy minor allele | 1.07 (0.59, 1.93) | 0.832 |
| Education | 0.84 (0.76, 0.94) | 0.003 |
| Diabetes | 0.43 (0.19, 0.96) | 0.039 |
| Modified Charlson-Deyo index | 1.26 (1.12, 1.42) | <0.0001 |
| ACPA | 4.59 (1.10, 19.08) | 0.036 |
MTHFR: methylenetetrahydrofolate reductase; ACPA: anticitrullinated protein antibody; CV: cardiovascular.