Risk factors for mortality, heart failure, and recurrent ischemia among 77 patients with rheumatoid arthritis (RA) and myocardial infarction (MI). Models adjusted for age at MI, sex, and year of MI.
| RA Characteristics at Onset of MI | N (%) or mean ± SD | Mortality HR (95% CI) | Heart Failure† HR (95% CI) | Recurrent Ischemia HR (95% CI) |
|---|---|---|---|---|
| RF and/or ACPA-positive | 54 (70) | 1.36 (0.73, 2.54) | 1.19 (0.52, 2.73) | 0.96 (0.51, 1.80) |
| Duration of RA, yrs** | 14.0 ± 9.5 | 1.23 (0.92, 1.65) | 1.27 (0.86, 1.88) | 0.95 (0.69, 1.32) |
| Rheumatoid nodules | 63 (82) | 1.29 (0.56, 2.97) | 1.11 (0.40, 3.07) | 0.72 (0.35, 1.49) |
| Erosions/destructive changes | 65 (84) | 1.76 (0.71, 4.35) | 1.84 (0.54, 6.30) | 1.60 (0.66, 3.85) |
| Severe extraarticular disease | 63 (82) | 1.42 (0.63, 3.20) | 0.99 (0.36, 2.69) | 0.98 (0.46, 2.08) |
| Methotrexate | 17 (22) | 0.83 (0.42, 1.66) | 0.93 (0.37, 2.38) | 0.91 (0.43, 1.93) |
| Hydroxychloroquine | 9 (12) | 1.75 (0.67, 4.59) | 0.67 (0.15, 2.88) | 0.82 (0.28, 2.37) |
| Other nonbiologic DMARD | 10 (13) | 2.36 (0.84, 6.62) | 0.45 (0.06, 3.52) | 1.09 (0.40, 2.95) |
| Corticosteroids | 25 (32) | 1.24 (0.68, 2.27) | 0.75 (0.32, 1.73) | 1.47 (0.79, 2.72) |