Multivariate analysis of dead versus alive in SSc (overall) and in dcSSc and lcSSc subsets. Data are from the univariate models comparing dead versus alive, adjusting for followup time for overall and subsets (data not shown). Education did not appear in the model as statistically significant.
| Significant Predictors | Data with All Significant Variables in the Regression Analysis OR (95% CI); p | Data Excluding ESR and Using % FVC and DLCO % Predicted as Continuous Variables OR (95% CI); p |
|---|---|---|
| Overall | ||
| Age | 1.066 (1.030–1.103); 0.0001 | 1.067 (1.032–1.102); 0.0001 |
| dcSSc | 3.817 (1.805–8.069); 0.0001 | 3.076 (1.499–6.310); 0.002 |
| sPAP > 40 mm Hg | 6.330 (3.042–13.172); 0.0001 | 5.025 (2.450–10.305); 0.0001 |
| FVC, % predicted < 70 | NS | — |
| FVC, % predicted (continuous) | — | 0.983 (0.066–1.000); 0.048 |
| Proteinuria | 3.295 (1.288–8.426); 0.013 | 2.700 (1.115–6.542); 0.028 |
| dcSSc subset | ||
| Age | 1.056 (1.010–1.103); 0.016 | 1.059 (1.016–1.104); 0.007 |
| sPAP > 40 mm Hg | 3.735 (1.289–10.826); 0.015 | 4.016 (1.504–10.720); 0.006 |
| FVC, % predicted < 70 | 3.039 (1.008–9.163); 0.048 | — |
| FVC, % predicted (continuous) | — | 0.972 (0.949–0.997); 0.027 |
| ESR > 20 mm/h | 3.001 (1.011–8.905); 0.048 | — |
| Proteinuria | 3.978 (1.110–14.255); 0.034 | 4.583 (1.449–14.500); 0.010 |
| lcSSc subset | ||
| Age | 1.076 (1.014–1.140); 0.015 | 1.080 (1.019–1.146); 0.010 |
| sPAP > 40 mm Hg | 4.101 (1.301–12.924); 0.016 | 3.515 (1.064–11.611); 0.039 |
| DLCO, % predicted < 70 | 6.162 (1.306–29.083); 0.022 | — |
| DLCO, % predicted (continuous) | — | 0.961 (0.933–0.991); 0.010 |
SSc: systemic sclerosis; dcSSc: diffuse cutaneous SSc; lcSSc: limited cutaneous SSc; ESR: erythrocyte sedimentation rate; FVC: forced vital capacity; sPAP: systolic pulmonary arterial pressure. NS: nonsignificant.