Least-squares means (95% CI) of clinical assessments in patients with fibromyalgia syndrome by 4 major haplotype structures. Statistical package PHASE v2.1.1 was used to construct haplotype structures; missing data were excluded (n = 2).
| Combined Allele* | n† | FIQ | BFI | PCS | MCS | BDI | STAI-1 | STAI-2 |
|---|---|---|---|---|---|---|---|---|
| CCTT | 347 | 59.8 (58.0–61.7) | 7.0 (6.3–7.7) | 35.7 (34.9–36.5) | 33.8 (32.6–35.1) | 19.1 (18.0–20.2) | 49.1 (47.8–50.4) | 51.1 (49.9–52.3) |
| TTCT | 157 | 59.7 (57.0–62.5) | 6.7 (5.6–7.7) | 36.0 (34.8–37.1) | 32.7 (30.9–34.5) | 18.6 (16.9–20.2) | 50.2 (48.3–52.1) | 51.3 (49.6–53.1) |
| TTCA | 93 | 61.2 (57.5–64.8) | 7.0 (5.6–8.3) | 35.9 (34.4–37.4) | 32.7 (30.3–35.1) | 19.0 (16.8–21.1) | 48.8 (46.3–51.3) | 51.4 (49.2–53.7) |
| CCTA | 8 | 61.6 (49.1–74.0) | 11.8 (7.3–16.3) | 38.0 (32.9–43.1) | 35.4 (27.3–43.6) | 18.6 (11.3–25.9) | 46.2 (37.9–54.6) | 47.0 (39.3–54.8) |
| p†† | 0.92 | 0.19 | 0.84 | 0.66 | 0.96 | 0.66 | 0.76 |
↵* Combined alleles are in their physical order along the chromosome: rs841, rs752688, rs4411417, rs3783641.
↵† Missing data were excluded from the analyses: for FIQ, n = 2; for BFI, n = 10; for BDI, n = 10; for STAI-1, n = 16; for STAI-2, n = 12.
↵†† p values from analysis of covariance, adjusted for age and sex. FIQ: Fibromyalgia Impact Questionnaire; BFI: Brief Fatigue Inventory; PCS: Physical Component Summary; MCS: Mental Component Summary; BDI: Brief Depression Inventory; STAI-1: State-Trait Anxiety Inventory-1; STAI-2, State-Trait Anxiety Inventory-2.