Table 2.

Regression analyses of correlation between genetic markers of rheumatoid arthritis (RA) susceptibility single-nucleotide polymorphisms (SNP) and Larsen score as a continuous time-dependent trait. Results for the 3 SNP displaying a zero-inflated negative binomial (ZINB) combined p value < 0.05 in the Early Rheumatoid Arthritis Study (ERAS) are shown together with the shared epitope and the TRAF1/C5 marker rs10760130. Results for those 5 markers using the same modeling technique applied on a previously reported dataset in the Norfolk Arthritis Register (NOAR) are presented to serve as replication. Results for all RA susceptibility SNP are available in Appendix 1.

				ERAS								NOAR
Chr.	Gene	SNP	Equation	Est.	Lo 95	Up 95	p	N obs	Z obs	Comb p	dy/dx	Est.	Lo 95	Up 95	p	N obs	Z obs	Comb p	dy/dx
1	PTPN22	rs2476601	Severity	−0.34	−0.50	−0.13	0.003	2150	684	0.011	−3.60	−0.02	−0.15	0.13	0.784	2089	655	0.667	0.14
1	PTPN22	rs2476601	Susceptibility	1.19	0.64	2.24	0.583	2150	684			1.15	0.84	1.58	0.387	2089	655
6	TAGAP	rs394581	Severity	−0.27	−0.42	−0.09	0.007	2155	678	0.024	−3.05	−0.02	−0.14	0.12	0.744	1910	600	0.781	−0.44
6	TAGAP	rs394581	Susceptibility	1.11	0.67	1.86	0.681	2155	678			0.92	0.68	1.22	0.550	1910	600
6	HLA-DRB1	Shared epitope	Severity	0.40	0.03	0.89	0.031	2013	614	5.12 E–05	5.36	0.42	0.23	0.63	6.79 E–07	2102	657	1.46 E–08	4.44
6	HLA-DRB1	Shared epitope	Susceptibility	3.11	1.76	5.48	8.87 E–05	2013	614			1.52	1.15	2.00	0.003	2102	657
9	TRAF1/C5	rs2900180	Severity	0.39	0.09	0.76	0.007	2161	684	0.024	2.96	0.08	−0.05	0.23	0.256	2168	689	0.037	1.56
9	TRAF1/C5	rs2900180	Susceptibility	0.84	0.50	1.41	0.502	2161	684			1.36	1.03	1.79	0.027	2168	689
9	TRAF1/C5	rs10760130	Severity	0.31	0.02	0.68	0.033	2161	684	0.074	2.18	0.07	−0.07	0.23	0.362	2164	689	0.264	1.14
9	TRAF1/C5	rs10760130	Susceptibility	0.77	0.43	1.36	0.365	2161	684			1.21	0.90	1.61	0.202	2164	689

Chr: chromosome; equation, severity/susceptibility: severity/susceptibility components of the ZINB model; est: estimate, expressed as percentage increase in Larsen score for the severity part of the model, or as OR for the susceptibility part of the model; Lo95: lower 95% CI; Up95: upper 95% CI; N obs: total no. observations; Z obs: among the N obs, no. observations with a Larsen score equal to zero; comb p: ZINB combined p value; dy/dx: time-averaged effect size in Larsen units (marginal effect of the model).