Differences in BAFF pathway expression in patients with idiopathic inflammatory myopathies, with or without at least 1 anti-RNA binding protein (RBP) autoantibody. Values are median (range) unless otherwise indicated.
| BAFF Pathway Expression | At Least 1 Positive RBP Autoantibody | No Positive RBP Autoantibodies | p |
|---|---|---|---|
| FL BAFF | 49,719.2 (10,061.6–139,265.6) | 35,184.9 (585.1–318,346.7) | 0.002 |
| ΔBAFF | 3740.9 (633.5–13,012.9) | 1861.5 (100.0–12,186.2) | < 0.001 |
| BAFF/ΔBAFF | 12.4 (7.3–26.9) | 17.2 (0.1–1457.9) | 0.02 |
| BAFF/APRIL | 8.1 (3.3–3562.1) | 4.5 (0.1–88.1) | < 0.001 |
| BCMA/BAFF-R | 0.4 (0.0–6.0) | 0.3 (0.0–3.6) | 0.05 |
APRIL: a proliferation-inducing ligand; BAFF: B cell-activating factor belonging to the TNF family; FL BAFF: full-length BAFF; BAFF-R: BAFF receptor; BCMA: B cell maturation antigen.