Table 4.

Results from the longitudinal zero-inflated negative binomial (ZINB) regression analysis of the Larsen score on the carriage of putative or confirmed rheumatoid arthritis susceptibility single-nucleotide polymorphisms (SNP) in the combined dataset of the Early Rheumatoid Arthritis Study (ERAS) and the Norfolk Arthritis Register (NOAR). Results are shown for SNP with a ZINB combined p value < 0.05 and for the shared epitope. All results are available in Appendix 1.

				ERAS + NOAR
Chr.	Gene	SNP	Equation	Estimate	Lo95	Up95	p	N obs	Z obs	Comb p	dydx
1	PTPN22	rs2476601	Severity	−0.19	−0.31	−0.06	0.005	4239	1339	0.016	−1.80
1	PTPN22	rs2476601	Susceptibility	1.16	0.82	1.64	0.390	4239	1339
2	AFF3	rs10865035	Severity	0.02	−0.11	0.18	0.743	4248	1338	0.030	−0.77
2	AFF3	rs10865035	Susceptibility	0.63	0.44	0.89	0.008	4248	1338
2	AFF3	rs1160542	Severity	0.02	−0.11	0.18	0.743	4279	1360	0.018	−0.83
2	AFF3	rs1160542	Susceptibility	0.61	0.44	0.86	0.005	4279	1360
6	HLA-DRB1	Shared epitope	Severity	0.41	0.22	0.64	6.33E-06	4115	1271	2.81E-10	4.84
6	HLA-DRB1	Shared epitope	Susceptibility	2.03	1.51	2.72	2.77E-06	4115	1271
6	TAGAP	rs394581	Severity	−0.16	−0.27	−0.04	0.011	4065	1278	0.039	−1.81
6	TAGAP	rs394581	Susceptibility	1.00	0.75	1.34	0.977	4065	1278
9	TRAF1	rs2900180	Severity	0.22	0.07	0.40	0.004	4329	1373	0.011	2.25
9	TRAF1	rs2900180	Susceptibility	1.10	0.83	1.45	0.509	4329	1373
12	KIF5A	rs775241	Severity	−0.15	−0.27	−0.02	0.029	4324	1370	0.014	−0.95
12	KIF5A	rs775241	Susceptibility	1.42	1.01	1.99	0.045	4324	1370

Chr: chromosome; equation, severity/susceptibility: severity/susceptibility components of the ZINB model; estimate: expressed as percentage increase in Larsen score for the severity part of the model, or as OR for the susceptibility part of the model; Lo95: lower 95% CI; Up95: upper 95% CI; N obs: total no. observations; Z obs: among the N obs, no. observations with a Larsen score equal to zero; comb p: ZINB combined p value; dy/dx: time-averaged effect size in Larsen units (marginal effect of the model).