ERAS + NOAR | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Chr. | Gene | SNP | Equation | Estimate | Lo95 | Up95 | p | N obs | Z obs | Comb p | dydx |
1 | PTPN22 | rs2476601 | Severity | −0.19 | −0.31 | −0.06 | 0.005 | 4239 | 1339 | 0.016 | −1.80 |
Susceptibility | 1.16 | 0.82 | 1.64 | 0.390 | 4239 | 1339 | |||||
2 | AFF3 | rs10865035 | Severity | 0.02 | −0.11 | 0.18 | 0.743 | 4248 | 1338 | 0.030 | −0.77 |
Susceptibility | 0.63 | 0.44 | 0.89 | 0.008 | 4248 | 1338 | |||||
2 | AFF3 | rs1160542 | Severity | 0.02 | −0.11 | 0.18 | 0.743 | 4279 | 1360 | 0.018 | −0.83 |
Susceptibility | 0.61 | 0.44 | 0.86 | 0.005 | 4279 | 1360 | |||||
6 | HLA-DRB1 | Shared epitope | Severity | 0.41 | 0.22 | 0.64 | 6.33E-06 | 4115 | 1271 | 2.81E-10 | 4.84 |
Susceptibility | 2.03 | 1.51 | 2.72 | 2.77E-06 | 4115 | 1271 | |||||
6 | TAGAP | rs394581 | Severity | −0.16 | −0.27 | −0.04 | 0.011 | 4065 | 1278 | 0.039 | −1.81 |
Susceptibility | 1.00 | 0.75 | 1.34 | 0.977 | 4065 | 1278 | |||||
9 | TRAF1 | rs2900180 | Severity | 0.22 | 0.07 | 0.40 | 0.004 | 4329 | 1373 | 0.011 | 2.25 |
Susceptibility | 1.10 | 0.83 | 1.45 | 0.509 | 4329 | 1373 | |||||
12 | KIF5A | rs775241 | Severity | −0.15 | −0.27 | −0.02 | 0.029 | 4324 | 1370 | 0.014 | −0.95 |
Susceptibility | 1.42 | 1.01 | 1.99 | 0.045 | 4324 | 1370 |
Chr: chromosome; equation, severity/susceptibility: severity/susceptibility components of the ZINB model; estimate: expressed as percentage increase in Larsen score for the severity part of the model, or as OR for the susceptibility part of the model; Lo95: lower 95% CI; Up95: upper 95% CI; N obs: total no. observations; Z obs: among the N obs, no. observations with a Larsen score equal to zero; comb p: ZINB combined p value; dy/dx: time-averaged effect size in Larsen units (marginal effect of the model).