APPENDIX 1.

Results from the longitudinal zero-inflated negative binomial (ZINB) regression analysis of the Larsen score on the carriage of putative or confirmed RA susceptibility single-nucleotide polymorphisms (SNP). Chr: Chromosome. Equation, severity/susceptibility: severity/susceptibility components of the ZINB model. Est: estimate, expressed as percentage increase in Larsen score for the severity part of the model, or as odds ratio (OR) for the susceptibility part of the model. Lo95: lower 95% CI. Up95: upper 95% CI. N obs: total number of observations. Z obs: among the N obs., number of observations with a Larsen score equal to zero. comb p: ZINB combined p value. dy/dx: time-averaged effect size in Larsen units (marginal effect of the model). NA: not applicable, because the SNP was either not genotyped or did not pass quality control.