Summary of studies of HLA-B*5801 in allopurinol-induced Stevens-Johnson syndrome (SJS).
| Study | Allele Frequency of HLA-B*5801 in Geographical Area of Study* (ethnicity studied) | HLA-B*5801-Positive Rate in Control Patients | HLA-B*5801-Positive Rate in Patients with SJS, TEN, or HS | OR (95% CI) |
|---|---|---|---|---|
| Taiwan 20053 | 0.15 (Han Chinese) | 20/135 | 51/51 | 580.3 (34.4–9780.9) |
| Europe 20085 | 0.008 (Europeans) | NA | 15/27 | 80 (34–187) |
| Japan 20084 | 0.0061 (Japanese) | NA | 10/18 | 62.8 (21.2–185.8) |
| Thailand 20096 | 0.077 (Thai) | 7/54 | 27/27 | 348.3 (19.2–6336.9) |
| Korea 20118 | NA | 41/432 | 9/9 | 179.24 (10.19–3151.74) |
| Australia 20119 | 0.0490 (New South Wales white) | NA | 5/6 | NA |
| Hong Kong 20127 | 0.15 (Han Chinese) | 4/30 | 19/19 | 123.5 (12.8–1195.1) |
↵* Data from allelefrequencies.net if not available from original studies. TEN: toxic epidermal necrolysis; HS: drug-induced hypersensitivity; NA: data not available.